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SELECTBIO Conferences Discovery Chemistry Congress

Abstract



Interfering Peptides Targeting Protein-Protein Interactions

Katja Arndt, Professor, University of Potsdam

Protein-protein interaction surfaces are attractive yet challenging targets for disease intervention. We present strategies to combine rational design with in-vivo and in-vitro selection systems and implementing competitive and negative design aspects to simultaneously select for affinity and specificity. Using such a semi-rational evolutionary approach, we generated interfering peptides (iPEP) specifically directed against the coiled-coil interaction motif as found in transcription factors such as Jun, Fos, AF10 and MITF. Modifications such as photo-switchable iPEPs for external control of inhibitor activity and D-peptides for protease resistance will be discussed as well. Specific targeting of tumor cells and efficient cellular delivery has been implemented by a modular virus system based on the adeno-associated virus. 


Add to Calendar ▼2015-02-17 00:00:002015-02-18 00:00:00Europe/LondonDiscovery Chemistry CongressDiscovery Chemistry Congress in Berlin, GermanyBerlin, GermanySELECTBIOenquiries@selectbiosciences.com