Abstract

Exosome-Mediated Functional Delivery of Integrins Promotes Cancer Progression

Lucia R. Languino, Professor of Cancer Biology, Thomas Jefferson University

Our investigations focus on exosome-mediated transfer of integrin surface receptors among subsets of cancer cells, and among cancer cells and the surrounding microenvironment.

Our recent studies demonstrate that exosomes from cancer cells contribute to horizontal propagation of integrin-associated invasive phenotypes in a paracrine fashion.

The presentation will cover the role of exosomal integrins in cancer progression, and will discuss their potential use as clinical biomarkers for non-invasive diagnosis and/or as therapeutic targets in cancer.