Abstract

One Process from Milligrams to Kilograms; Efficient Drug Substance Development Enabled by Continuous Manufacturing Technology

Eric Fang, Chief Scientific Officer, Snapdragon Chemistry, Inc.

The nature of continuous manufacturing creates new opportunities for efficient and single-cycle process development.  The use of automated, well characterized lab reactors with tight control over process parameters and rich data collection are enabling new ideas in chemical process development.   Lab reactors designed to accurately model production reactors facilitate efficient development of continuous manufacturing processes.  Examples of this scale-by-design process development will be presented, with particular emphasis on reaction types for which flow technology is truly enabling.