Abstract

Safe Synthesis using Flow Chemistry

Thomas Wirth, Professor, Cardiff University

Safe chemistry with hazardous compounds is in the focus of our current research. The generation and use of diazo derivatives in flow systems has led to advances important for pharmaceutical industries. Thesynthesis of radiopharmaceuticals by the rapid, flow chemistry-assisted incorporation of [18F]-fluoride is demonstrating further advances in the generation of important PET radiotracers such as [18F]-FDG (using segmented flow in microreactors) and [18F]-DOPA.