Tunable Asymmetric Photochemical Induction in Flow
Amanda Evans, Assistant Professor, California State University Fullerton
This talk will focus on the use of circularly polarized (cp), or
“chiral”, light as a supramolecular enantioinductive field for the
generation of asymmetric building blocks as a continuous photochemical
process. Enantioselective chiral photolysis of small molecules has
already been achieved under batch, solid-phase conditions: using
synchrotron-sourced cp light, asymmetric photolytic selectivities of up
to 4.2% enantiomeric excess (e.e.) have been reported. To determine the
optimal wavelengths to use for irradiation with cp light for any given
molecular building block, CD and anisotropy spectra for each building
block of interest have been generated in two different solvents (water,
hexafluoroisopropanol) across a range of wavelengths (130-400 nm).
These spectra have been used to optimize conditions for a series of
continuous photochemical processing experiments performed using
synchrotron-sourced cp light as the sole source of enantioinduction for a
family of small molecules. A mechanism for this enantioinduction and
methods for enhancing the initial selectivities observed will be
discussed, and predictive approaches for describing the behavior of
similar small molecules will also be presented.
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