Abstract

Novel Microfluidic Platforms for Scale-Up Production and Autonomous Self-Optimization

Dong-Pyo Kim, Yonsan Chaired Professor, Center for Intelligent Microprocess of Pharmaceutical Synthesis, POSTECH

Flow chemistry in the confined microfluidic space enables easy up-scaling production at precise controlled conditions. In the talk, we show the assembly of 16 numbering-up 3D printed metal microreactor to render high productivity up to 20 g for 10 min operation of subsecond ultrafast chemistry. And, hexagon-shaped 3D printed polymer module of photomicroreactor with solar concentrator leaded to facile assembly into serial and radial reconfiguration for high throughput of synthesis. In addition, for scalable production of emulsions, compact 3D printed droplet generator was devised by array of 40 drop-makers with a 3D void geometry and a flow distributor, producing microgels and microparticles. Finally, we explore ultrafast flow chemistry by autonomous self-optimizing platform that accelerates the optimization and screening of complex chemistry.