Process Intensification for Chemo-Enzymatic Reactions
Rodrigo Souza, Associate Professor, Chemistry Institute , Federal University of Rio De Janeiro
Continuous-flow technology has arrived at the drug manufacturing companies in order to avoid waste of time and tries to make process chemistry more efficient. It allows the development of cascade reactions, combining different steps without the need of isolation and purification, in a cost effective way in terms of time and money. During the last years our group has focused efforts on the development of chemo and enzymatic methodologies towards the synthesis of fine chemicals, intermediates and final APIs, which are important for the chemical industry in Brazil. Several examples will be shown, some of them featuring cascade chemo-enzymatic reactions, on the synthesis of levetiracetam, ethambutol, crizotinib, donepezil, among others.
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