Advance in APPI-MS/MS-IMS Approaches For Real Time Sensing of Structural Isomers in Flow Chemistry
Maarten Honing, Professor, Maastricht University, M4I Institute Maastricht MultiModal Molecular Imaging
In this presentation, the potentials for the in-situ detection of structural isomers is discussed. Main attention will be given to a classical Diels-Alder reaction, which besides some particular “synthesis byproducts”, also leads to the formation of structural isomers with the same molecular mass. In classical on-line MS detection these two isomers are not detected. A novel approach, using the difference in fragmentation energies and ion mobility separation , reveal the structures of both isomers allowing to elucidate the reaction mechanisms underlying their formation.
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