Abstract

Engineering of Cells For Cancer Immunotherapy

Noriko Shimasaki, Research Assistant Professor, National University of Singapore

The dramatic clinical efficacy of T lymphocytes expressing chimeric antigen receptors has been demonstrated in B-cell malignancies. The great success suggests a potential of immune-cell based therapy for other hematological and solid malignancies. We have translated technologies developed in our research laboratory into large-scale procedures in compliance with current Good Manufacturing Practices guidelines. The developed methods are implemented to prepare cell products for infusion to patients. The translation into clinical application at an academic facility will be discussed.