Abstract

Nano Analytical Tools for Extracellular Vesicles

Shivani Sharma, Associate Director, University of California, Los Angeles

The analysis of exosomes and other extracellular vesicles (EVs) in body fluids could in future be the standard diagnostics in medicine, with growing evidence that the size, number concentration and biological composition of EVs are influenced by disease-including cancer, neurodegenerative diseases, and other anomalies and thus comprise of clinically relevant information. However the best utilization of this information warrants standardization of EVs for any downstream diagnostic analysis. I will discuss the application and impact of key EV metrology tools including Atomic Force Microscopy and Force Spectroscopy as well as recent findings in brain, breast and prostate cancer cell models.