Abstract

Advances in Microfluidic CTC Assays and Their Application to Patient Management

Lorena Dieguez, Staff Researcher, INL

Circulating Tumor Cells (CTCs) are the holy grail of liquid biopsy biomarkers in oncology, however they are very rare, difficult to isolate and have not yet demonstrated clinical utility. Microfluidics has demonstrated numerous advantages for CTC isolation and characterization, with increased sensitivity and throughput, enabling their implementation in clinical routine. In this talk, we present our most recent work for the development of robust CTC assays, and their application in several clinical scenarios.