Abstract

Bridging the Gap Between Academia and Industry by Developing Robust and Scalable Biocatalytic Process in Continuous Production

Francesca Paradisi, Professor of Pharmaceutical and Bioorganic Chemistry, University of Bern

To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate the reliability of enzyme-based methodologies directly applied to the production of high value products. Here the merging of flow technology with biocatalysis will be presented, showcasing the rapid evolution we achieved in our research group moving from analytical to preparative scale for the synthesis of valuable chemicals, while tackling a range of limitations such as substrate insolubility and cofactor recycling.