Abstract

Human Microphysiological Systems for Disease Modeling

George Truskey, R. Eugene and Susie E. Goodson Professor of Biomedical Engineering, Duke University

Microphysiological systems (MPS) are small scale three-dimensional models of key structural or functional units of human organs or tissues.  Such systems can be used to model diseases and test therapeutics.  The strengths and limitations of various models will be discussed with a focus on vascular models, including system design and the use of primary and stem cell derived cells.  Applications of these systems to model genetic and acquired diseases and evaluate therapeutics will be described.