Abstract

Improving Dissolution of Poorly Water Soluble Drug by Incorporation of Precipitation Inhibitors using Mathematical Model

Akhila Ravikumar, , JSS College of Pharmacy, Mysuru

The purpose of the present study was to investigate poorly water soluble drug in a intricate process of drug absorption which captures two sginificant factors  solubility and intestinal pemeability which  is overcomed via (1) Establising  an in vitro methodology - to study dissolution and precipitation in early stages of drug development were low compound composition and high through output are necessary (2) To develop a mathematical model for a mechanistic explanation of genarated in vitro dissolution and precipitation data and (3) extrapolate invitro data to in vivo situations using physiologically based models to predict oral drug absorption . Solvent quenching studies were performed in biorelavant media to monitor the precipitation of  a poorly water soluble weak base.  After developing a dissolution – precipitation inhibitor  model from the data, it was resolved for a simplified, physiologically based absorption model to predict clinical pharmacokinetic profiles. The model  helped to assist the consequences of supersaturation behaviour of compounds. In overstudy, we could summaried the novel approach for the combination  of experimental dissolution/precipitation methodology with a mechanistic model for the prediction of human drug absorption kinetics. This comes within reach of dissolution and precipitation theories and explains the prediction of in vivo oral absorption by the apply of physiological based models.