Abstract

Engineering Multicompartment Organ-Chip Systems

Elisabeth Verpoorte, Professor, Pharmaceutical Analysis, University of Groningen

The miniaturized total chemical analysis system has been successfully repurposed over the past twenty years or so for engineering cellular microenvironments which more faithfully mimic in vivo conditions for cell- and tissue-based studies. Organs-on-a-chip are a recent outgrowth of this effort, comprising systems that extend beyond microfluidic perfusion culture to allow the establishment of microphysiological systems comprising interconnected multiorgan systems. This presentation will consider a couple of examples of such systems out of our labs in Groningen for the elucidation of organ (inter)actions in the gastrointestinal tract and the liver.