Abstract

Application of Brain Model Technology

Alysson Muotri, Professor, Director of the Stem Cell Program, University of California-San Diego

Brain organoids, generated from stem cells, have created opportunities to study morphological and molecular aspects of human neurodevelopment However, it is unclear if these organoids could generate sophisticated network activity. The Muotri lab has generated brain organoids with oscillatory waves similar to fetal stages of human development. Implications for human disease and brain evolution will be discussed.