Abstract

Optical Molecular Imaging and Sensing in Humans Using Chemical Probes

Mark Bradley, Professor of Therapeutic Innovation, Precision Healthcare University Research Institute, Queen Mary University of London

The EPSRC Interdisciplinary Research Collaboration (IRC) ‘Proteus’ seeks to address the challenge of lung diseases by developing a chemistry and optical fibre based healthcare technology platform that combines physiological sensing with multiplexed optical molecular imaging. This technology enables in situ measurements in the distal lung to assess tissue function while generating and characterising unique signatures of pulmonary disease. In my talk I will describe the chemistry, the optical fibre technology and the CMOS SPAD detectors behind the teams optical imaging platforms and illustrate their in vivo application with the detection of bacterial infection deep in the human lung and the analysis of fibrosis.