Abstract

Single Cell Sequencing For Predicting Chemotherapy Response in Ovarian Cancer

Timothy K. Starr, Assistant Professor, University of Minnesota

Women with ovarian cancer suffer from high rates of recurrence and chemotherapy resistance leading to mortality. We have implemented a prospective study that incorporates single cell RNA sequencing, along with other genomic and transcriptomic analyses, to identify cellular biomarkers that predict response to chemotherapy. The ability to predict response to front-line chemotherapy would enable earlier implementation of alternative therapies when treating women with ovarian cancer.