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SELECTBIO Conferences Track One


Particle and Cell Manipulation Using Surface Acoustic Waves

Ye Ai, Assistant Professor, Singapore University Of Technology And Design

Acoustics has emerged as one of the most promising non-invasive techniques for particle manipulation in microfluidics. In this presentation, I will talk about a surface acoustic wave (SAW)-based microfluidic device for manipulating micro/nano-scale particles and biological cells. The microfluidic device is comprised of two components, a SAW transducer and a microfluidic channel made of polydimethylsiloxane (PDMS). The SAW transducer was fabricated by patterning two pairs of interdigital electrodes on a lithium niobate (LiNbO3) piezoelectric substrate. When exciting the SAW transducer by AC signals, a standing SAW field is generated across the cross-section of the channel. I will demonstrate the patterning of micron-sized particles (e.g. polystyrene particles and red blood cells) and nanometer-sized particles (e.g. carbon nanotubes). The mechanism of the SAW-based patterning technique will be discussed. The same type of particles with varying sizes responds to the SAW field differently, leading to a potential for cell separation. I will also demonstrate the separation of E. coli bacteria from peripheral blood mononuclear cell (PBMC) samples using a standing SAW field. I envision that the merging of acoustics and microfluidics could enable various particle and cell manipulations needed in microfluidic applications.

Add to Calendar ▼2015-11-19 00:00:002015-11-20 00:00:00Europe/LondonTrack