Abstract

MSCs for Vascular Regeneration and Wound Healing

Thomas Ritter, Senior Lecturer, National University of Ireland

Mesenchymal stem (or stromal) cells (MSCs) are non-hematopoietic adult stem cells with multi-lineage differentiation potential. They can be isolated from bone marrow and various other readily accessible adult tissues and have the capacity to extensively proliferate in vitro and be expanded to clinically useful numbers. It has been demonstrated both in vitro and, to a lesser degree, in vivo, that MSCs possess potent immunosuppressive properties, predominantly mediated through paracrine effects on processes such as inflammation, tissue repair and angiogenesis. Considering the regenerative potential and profound immunosuppressive effects of MSCs, MSC therapy is a promising approach for the treatment for vascular regeneration and would healing.  We have recently explored the use of MSCs in pre-clinical models of skin ulcer and critical limb ischemia (CLI). Based on pre-clinical efficacy and toxicity data we have received a manufacturing license and clinical trial authorization for a CLI study in Ireland.