08:30 | Morning Coffee, Tea and Networking |
| Session Title: The Impact of Microfluidics and POC Diagnostics into the Biodetection Space |
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09:00 | Lab on Discs for Diagnostics and Process Control Anja Boisen, Professor, Department of Micro and Nanotechnology, Technical University of Denmark, Denmark
The optics and mechanics from a DVD player can be used to realize compact and sensitive sensor systems. By rotating a disc with integrated microfluidic channels it is possible to manipulate liquid samples such as blood – performing crucial operations like separation, valving and mixing. We integrate cantilever-based sensors, electrochemistry, surface enhanced Raman spectroscopy (SERS), nanoparticles and resonating strings with centrifugal microfluidics. The sensors are read out by a DVD pick-up head which can perform transmission, absorption measurements and which can detect nm deflections. Also, electrodes are integrated on a disc platform, facilitating the electrochemical measurements. Applications within diagnostics and process monitoring will be highlighted. |
09:30 | | Keynote Presentation Wearable Electrochemical Sensors: Toward Lab on the Skin Joseph Wang, Distinguished Professor, SAIC Endowed Chair, University of California-San Diego, United States of America
This presentation will discuss recent developments in the field of wearable electrochemical sensors integrated directly onto both textile materials and on the epidermis for various non-invasive monitoring applications. |
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10:15 | Bioinspired Microfluidics Dermot Diamond, Professor, Principal Investigator, Insight Centre for Data Analytics, National Centre for Sensor Research, Dublin City University, Ireland
Microfluidics will transform from engineering inspired 2D largely passive systems to Bioinspired 3D systems incorporating advanced functionalities such as self-awareness and self-maintenance. These features will be incorporated through incorporation of stimuli-responsive materials exhibiting biomimetic characteristics. |
10:45 | Coffee, Tea and Networking |
11:15 | Magnetic Bead Based Detection of Biomarkers by Phase Shift Measurement in Complex Sample Matrices Stefan Scheuermann, Researcher, Fraunhofer IPA, Germany
BeadTRAP - a highly efficient detection technology for the direct measurement of biomarkers in complex samples. The technology is based on alternating magnetic fields forcing magnetic particles into oscillation, combining the power of purification with highly sensitive detection of biomarkers. |
11:45 | Planar Waveguide Biosensor Technology for Next Generation Point of Care Diagnostics Reuven Duer, Founder & CEO, Proactive Diagnostics, United States of America
I’ll be presenting a novel and disruptive detection technology for Point of Care diagnostics. The presentation includes the underlying physics, implementation solutions and testing data of this unique technology platform. |
12:15 | Plasmonic Nanopores for Analysis and Detection of Biomolecules Andreas Dahlin, Associate Professor, Chalmers University of Technology, Sweden
Plasmonic nanostructures have been used in biosensor applications for over 10 years. Following advancements in nanofabrication techniques, more and more complex structures have been developed. Still, the commercial technique of surface plasmon resonance remains the golden standard for studying biomolecular interactions by refractive index changes on a surface. This is mainly because no nanofabrication is needed as the method only utilizes a planar thin gold film and the resolution in surface coverage is very high (below 0.1 ng/cm2). However, one can envision unique advantages of nanostructured sensor surfaces based on utilizing the structure itself. In this talk I will give examples of such applications based on plasmonic nanopores, i.e. nanoscale apertures in thin gold films. For instance, I will describe how polymer-functionalized nanopores act as molecular filters or nanoscale sieves, offering the possibility to isolate small molecules to be detected from complex mixtures. This can be utilized to improve specificity in detection of small analytes. Various other applications where the plasmonic nanopores provide special benefits will also be presented. |
12:45 | Networking Lunch in the Exhibit Hall -- Meet the Exhibitors and View Posters |
13:30 | TB or not TB Chris Adams, Head of Biosensor, QuantumDx, Ltd., United Kingdom
With 8.6 million new cases diagnosed every year, and an estimated 3 million unreported cases in remote village locations, TB is still a leading cause of death worldwide. This, combined with increasing levels of drug resistance, means that the need for a portable device able to deliver accurate 15-20 minute turnaround DNA-based classification is ever more acute. Chris Adams, Head of Biosensor Development at QuantuMDx, will present the company’s development of a handheld sample-to-result device that will make personalised medicine affordable and accessible, even in resource scarce settings. The device delivers referral laboratory-standard results at the point of care. It is operated simply and with on-board power. The device performs DNA extraction, PCR and either multiplex label-free microarray detection using a silicon nanowire or optical based assays QuantuMDx has also developed a novel DNA sequencing technology for possible de novo or discovery application of the technology in the future. Excitingly the company has recently hit the significant milestone of full integration of the platform in an beta prototype. Clinical trials are expected to kick off later this year, with commercialisation expected in 2018.
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14:00 | From Academia to Commercialization – A Case Study Martin Peacock, Director, Zimmer and Peacock
We use a Zimmer and Peacock case study, where we have partnered with a UK University to commercialize their technology, and offer this as a template to work with other academic and start-up teams to commercialize their technology. |
14:30 | Magneto-Optical Sensing at Point-of-Need Jenna Bowen, Co-Founder, Cotton Mouton Diagnostics Ltd., United Kingdom
First developed as an in-field diagnostic for malaria, CMD’s innovative magneto-optical technology has been transformed into a generic sensing platform capable of detecting a variety of markers. Reduced to a small footprint and capable of providing results within minutes, the CMD system is ideally suited to point-of-need applications across the healthcare sector and beyond. |
15:00 | | Keynote Presentation Mobile Imaging, Sensing and Diagnostics Using Computational Photonics Aydogan Ozcan, Chancellor's Professor, University of California-Los Angeles; Associate Director, California NanoSystems Institute (CNSI), United States of America
In this presentation I will discuss some of the emerging applications and the future opportunities created by the use of mobile phones and other consumer electronics devices for the development of next-generation imaging, sensing and diagnostics tools through computational photonics techniques. |
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15:45 | Controlling and Measuring the Flow of Charged Species through Nanopores Mark Platt, Senior Lecturer, Loughborough University, United Kingdom
Nanopore technologies offer single particle analysis, being used to sequence DNA, detect proteins, cells or nanomaterials. We review recent results developing multiplexed sensors, using aptamer modified nanomaterials and nanopores for the detection of metal ions, proteins and bacteria. |
16:15 | Use of Synthetic Recognition Elements for the Thermal Sensing of Biomarkers Marloes Peeters, Deputy Director of Chemical Engineering, Newcastle University, United Kingdom
Molecular Imprinted Polymers (MIPs) are synthetic receptors with recognition sites that are complementary to the template in their size, shape, and orientation of functional groups . These microparticles are synthesized for the neurotransmitter noradrenaline with the optimal composition and binding conditions being determined via optical batch rebinding experiments. Next, the obtained MIPs are mixed within screen-printed inks to produce mass-producible bulk modified MIPs screen-printed electrodes (MIP-SPEs). In this contribution, the supporting surface which the MIP-SPEs are screen-printed upon are explored to deviate from conventional polyester, to polyvinylchloride, tracing paper and household-printing paper. The performance of the MIP-SPEs are measured using the Heat-Transfer Method (HTM), a straightforward and low-cost detection technique based on thermal resistance. At first, the noise on the signal is minimized by adjusting the settings of the temperature feedback loop. Second, the response of the MIP-SPEs to noradrenaline is measured and compared for the different substrate materials. Sensors printed onto paper are considered in further experiments as their response to noradrenaline is the highest and advantageous material properties, including sustainability and flexibility of the material. Subsequently, dose-response curves are determined by simultaneously measuring HTM and Thermal Wave Transport Analysis (TWTA). The latter is a new thermal detection method that relies on the use of thermal waves and has the advantage of a short measurement time (2 min). With these thermal methods, it is possible to specifically detect noradrenaline in aqueous solutions and quantify it at relevant concentrations. In summary, by combining synthetic receptors with thermal measurement techniques it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules. Through exploring novel SPE substrates, a system is designed that is flexible and holds potential for the use in commercial biomedical devices and complex sensor architectures.
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16:45 | | Keynote Presentation Body Sensor Networks: Current State of the Art and Future Directions Guang-Zhong Yang, Director and Co-Founder of the Hamlyn Centre for Robotic Surgery; Professor, Imperial College London, United Kingdom
Recent advances in surgery have made a significant impact on the management of major acute diseases, prolonging life and continuously pushing the boundaries of survival. Despite increasing sophistication of surgical intervention, complications remain common and poorly understood, contributing significantly to mortality and morbidity. Surgical site infections, catheter related sepsis, wound dehiscence and gastrointestinal anastomotic leakage are recognized complications following surgical interventions or invasive monitoring of critically ill surgical patients. Current methods for detecting these complications rely on episodic clinical examination with 'snap shot' laboratory testing. This talk focusses on the development of new sensing technologies that can be seamlessly integrated with existing surgical appliances to provide continuous sensing and early detection of these adverse events, thus minimizing post-operative infection, complication, and readmission. |
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17:15 | | Keynote Presentation Host Biomarker Detection as Diagnostic Indicators of Infection Karen Kempsell, Senior Project Team Leader, Public Health England, United Kingdom
Host Biomarkers have been used in diagnosis of disease and other conditions for many decades e.g. blood gases, creatinine, CRP, PCT. Clinical diagnoses already rely heavily on these for patient disease management and informing treatment and care pathways. There is a historic precedent for their use e.g. Lateral flow devices (LFDs) e.g. pregnancy test i.e. hCG. Detection of these markers are useful as diagnostic tools, particularly in incidences where infections are hard to diagnose e.g. extra-pulmonary Tuberculosis. The market for biomarker-based biosensor devices is considerable and interest in further diagnostic opportunities is mounting. Here we present evidence to support the use of biomarkers for disease diagnosis and outline translational pipelines and platforms and issues with route to market, particularly for new Tuberculosis diagnostics.
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17:45 | Oxytocin-Enabled Impedimetric Biosensor for Zinc and Copper Ions Kiran Kumar Tadi, Post-Doctoral Fellow, Institute of Chemistry, The Hebrew University of Jerusalem, Israel
Oxytocin is reported for the first time as a recognition layer of a biosensor. The usefulness of this methodology is validated by differentiating between sera samples of multiple sclerosis patients and healthy ones based on zinc to copper ratio. |
18:15 | Microfluidics & Hypermobility for Health 4.0 Ali Tinazli, Head of Healthcare & Life Sciences Strategy, HP, Inc., United States of America
New imperatives of healthcare are focusing on prevention, personalization of diagnostics and treatment, and democratization, including access to everyone, anywhere, anytime at a low cost. The technology convergence in medicine is enabled by the powerful combination of microelectronics, microfluidics, distributed network and data analytics. |
18:45 | Close of Conference |