Conference Registration, Materials Pick-Up, Coffee, Tea and Networking

Technology Spotlight:
Independent and Controllable • Intelligent Innovation for the Future — Core Technologies and Application Practices of Flow Chemistry by OU SHISHENG
Haiyu Wang, Application Director, OU SHISHENG (BEIJING) TECHNOLOGY CO., LTD.

Flow Chemistry Asia 2026 focuses on core topics such as 3D printed reactors and microfluidics. As a leading domestic provider of flow chemistry solutions, Oushisheng has achieved full independent R&D of equipment, breaking external dependence. In this speech, Wang Haiyu, Application Director, will share the technical advantages of the company's core products. Combining typical application cases from Fuzhou University and East China University of Science and Technology, he will explain how flow chemistry solves the pain points of traditional processes. Based on the conference hot topics, he will also discuss the prospect of technology integration application and industrialization path, providing actionable references for the industry.

Mid-Morning Coffee and Tea Break -- Visit Exhibitors and View Posters

Networking Buffet Lunch in the Hotel Restaurant

Process Development of a Diastereopure Drug Intermediate via Flash Chemistry, Continuous Packed-bed Hydrogenation and Enzymatic Kinetic Resolution
Fanfu Guan, Senior Scientist, Jiangsu Hengrui Pharmaceuticals Co. Ltd., China

New technologies, such as continuous flow chemistry and enzymatic catalysis, are reshaping drug development and production, assisting in synthesis of drug with precision. HRS-1358 is a novel PROTAC molecule designed to target and degrade the estrogen receptor (ER). It potently and selectively degrades ER, inhibits ER transcriptional activity and downstream signaling, thereby suppressing tumor cell proliferation and exerting anti-tumor effects. The synthesis of key drug intermediate 1 possessing two sterically hindered adjacent stereocenters lacking chelating heteroatoms, presents significant challenges. To meet the clinical trial demands, the new synthetic route in Figure 1 was developed by adopting continuous flash chemistry, continuous packed bed hydrogenation and enzymatic kinetic resolution, raising the yield by two-fold to 32.5% and reducing the step to three steps.

Technology Spotlight:
Chemometrics with AI: From Classical Models to AI-Enhanced Models
Liangfeng Guo, Chemometrics Lead Scientist, Paeonia Innovations

Spectral analysis is evolving from classical chemometrics, such as PCA and PLS, toward AI-enhanced architectures better suited for the non-linearities and high-dimensional noise of lab-scale flow chemistry. This session examines how deep learning enables automated feature extraction and complex deconvolution, allowing for the precise identification of chemical signatures within the overlapping molecular fingerprints of complex synthesis. By transcending linear models, researchers can maintain analytical integrity during the critical transition from benchtop R&D to pilot-scale validation. This presentation highlights the synergy between computational spectroscopy and miniaturized Mid-IR hardware. By embedding neural networks into ultra-compact spectrometers, it is possible to compensate for reduced optical paths and achieve lab-grade accuracy in-line. For process intensification, these instruments facilitate a "Smart Lab" environment, providing the instantaneous kinetic feedback required to dynamically optimize reaction parameters and ensure rigorous quality control throughout the experimental and pilot phases.

Mid-Afternoon Coffee and Tea Break -- Visit Exhibitors and View Posters

Efficient and Scaled-up Continuous-flow Synthesis of Pharmaceuticals and High-value Products in Microreactors
Yuanhai Su, Professor, Shanghai Jiao Tong University, China

This report focuses on the continuous-flow synthesis and scale-up of high-value chemicals, especially pharmaceuticals. Key systems include the photobromination of oxime ethers, photocatalytic oxidation of dihydroartemisinin to artemisinin, and cyanation of benzyl chloride to phenylacetonitrile. Using self-developed microreactors, limitations of traditional batch processes—such as heat, mass, and photon transfer inefficiencies, and scale-up effects—were overcome. By combining numbering-up and scaling-up strategies, the coupling of transport phenomena and reactions in microchannels, along with reaction kinetics, was systematically studied to guide scale-up. The resulting high-throughput microreactor platform enables highly selective, continuous, large-scale synthesis of various high-value chemicals, including pharmaceutical intermediates and active ingredients. This work provides theoretical and technical support for the green transformation of the high-value chemical and pharmaceutical industries.

Technology Spotlight:
Jingjin Pump Applications and Solutions in Flow Chemistry
Meichen Luo, Technical Sales Engineer, Hangzhou Jingjin Technology Co., Ltd.

Continuous flow chemistry requires stable, reliable liquid delivery, but conventional pumps face challenges including pulsation, clogging with solids or viscous fluids, complex maintenance, seal failures with reactive chemicals, and metal contamination.
This presentation introduces Jingjin Pump, featuring four targeted solutions:

1.    JINGJIN Precise feeding system with triplex plunger – Designed for demanding applications, particularly solids-containing and high-viscosity liquids.

2.    JINGJIN Seconds-Switchable Integrated Flow Path Pump – Entire pump head replaces in <60 seconds, reducing downtime by >90%; fault recovery in under a minute.

3.    JINGJIN Lithium Reagent Pump – Specialized design prevents crystallization and leakage when handling air-sensitive lithium reagents.

4.    JINGJIN Metal-Free Pump – Achieves <1 ppb metal leaching (ICP-MS verified) with =0.2% accuracy for semiconductor and ultra-pure applications.

All Jingjin pumps feature proprietary in-house cam design achieving pulsation < ±0.02 mL/min, and 36-point pressure-flow calibration maintaining ±0.5% accuracy across 0–42 MPa. Flow rates range from 0.003 mL/min (lab) to 1000 L/h (production). Widely adopted across chemical, pharmaceutical, and semiconductor industries.

Technology Spotlight:
Continuous-Flow Photochemistry: From Laboratory to Industrial Implementation
Hua Chao Jun, General Manager, Zhejiang Brilliance Technology Co., Ltd.

Flow photochemistry technology is revolutionizing organic synthesis paradigms through its exceptional light penetration efficiency, precise reaction parameter control, and inherent safety features. This report systematically elucidates the core advantages of flow photochemistry, including how microchannel structures overcome challenges such as photon transport heterogeneity and amplification effects inherent in traditional batch photoreactions. We will focus on innovative reactor design strategies and their application in specific reaction types through continuous processing approaches. Additionally, the report explores future trends in process intensification, automated platform integration, and continuous manufacturing applications, aiming to provide novel solutions for efficient, green, and sustainable synthetic chemistry.

Networking Reception with Beer -- Engage with Exhibitors and Colleagues

Close of Day 1 of the Conference

Morning Coffee, Tea and Networking

Continuous Flow Synthesis Towards Local API Manufacturing
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

Africa has a variety of formulation companies; however the active pharmaceutical ingredients (APIs) are generally imported, making medications unaffordable to many patients in developing countries.

When micro reactor technology and flow chemistry was introduced it was seen as a research and development tool, however it is now being used to produce large quantities of product, especially in Asia.

To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. A selection of cases studies will be presented.

Mechanistic Insights and Process Intensification of Aromatic Nitration Based on Flow Chemistry
Guangsheng Luo, Professor, Tsinghua University, China

Aromatic nitration, a hazardously complex process, poses serious risks for nearly 200 years. Key challenges include the decoupling of reaction kinetics and transport behavior, the suppression of side reactions, and the improvement of process safety. Flow chemistry offers a powerful integrated tool for both mechanistic exploration and process intensification. By enhancing mass transfer and heat management in continuous flow systems and precisely controlling reaction conditions, a kinetic research methodology for aromatic nitration and kinetic models for typical nitration processes were established. For the first time, a mechanism for suppressing over-nitration side reactions through dynamic regulation of thermodynamic properties in continuous flow system was identified, significantly improving the selectivity of nitration reactions. Furthermore, by integrating the concept of countercurrent flow with flow chemistry principles, a novel microflow reaction mode and its corresponding optimization strategy were developed. This mode reduces the exothermic rate of the nitration reaction while simultaneously increasing the spatiotemporal conversion rate. The flow nitration strategy, combining the novel mechanism and microflow mode, has been successfully applied to various typical nitration processes. It provides a safer and more efficient nitration protocol with higher selectivity, demonstrating the advantages of the proposed strategy.

Co(II) Mediated Electro-Oxidation of Toluene and p-Xylene with Microchannel Flow Cell Reactor
Kai Wang, Associate Professor, Department of Chemical Engineering, Tsinghua University, China

The oxidation of methylarenes is a crucial reaction for preparing fine chemicals such as aromatic aldehydes and aromatic acids. Conventional oxidation methods much rely on high-temperature and high-pressure conditions or hazardous reagents, leading to safety risks and environmental pollution. Electro-oxidation offers an alternative due to its advantages of high atomic economy and mild reaction conditions. Among different electro-oxidation approaches of methylarenes, indirect oxidation mediated by Co(II) in organic systems holds the potential to solve the problems. We therefore constructed a Co(II)-mediated indirect electro-oxidation system for methylarenes using acetic acid as the solvent, cobalt acetate as the electrochemical mediator, and n-Bu4NBF4 as the supporting electrolyte. Facing complex product distributions and selectivity control challenges, an AI algorithm was integrated to develop and optimize a selective electro-oxidation process, achieving a balance between product yield and energy consumption. A continuous-flow reaction platform centered on an electrochemical microreactor was further designed, enabling the electro-oxidation with high yield and selectively.

Mid-Morning Coffee and Tea Break -- Visit Exhibitors and View Posters

Microreactor–Plasma Integration: A Novel Process Intensification Technique
Liangliang Lin, Associate Professor, Jiangnan University, China

This presentation introduces a novel process intensification technique based on the integration of microreactor and plasma technology. By combining the advantages of both platforms, this approach offers a range of key benefits for applications in chemistry and chemical engineering, including continuous operation, non-equilibrium states, green and solvent-free reactive atmospheres, and high-purity products with narrow size distributions. In this lecture, representative setups developed by our group will be presented, along with illustrative examples of this novel technique applied to nanomaterials synthesis, surface modification, additive manufacturing, and beyond. This work is expected to find broad applications in fields such as chemical engineering, chemistry, advanced materials, and bioscience.

Continuous Flow Metallaphotoredox Stereodivergent Semi-hydrogenation and Semi-deuterogenation of Alkynes
Wai Chung Fu, Assistant Professor, City University of Hong Kong, Hong Kong

Alkenes are ubiquitous structural motifs in pharmaceuticals, agrochemicals, and materials science, while their stereoselective synthesis has been a pivotal endeavour in organic chemistry.  Stereoselective semi-hydrogenations provide straightforward access to both E- and Z-alkenes from readily available alkyne precursors, but traditional methods often suffer from poor scalability, over-reduction, limited substrate scope, and reliance on hydrogen gas.  Herein, we discuss two metallaphotoredox systems that enable stereodivergent semi-hydrogenation and semi-deuterogenation of alkynes.  We reveal new factors that control the stereoselectivity of both reactions, such as by varying the acid co-catalysts or the residence time in flow.  Both E- and Z-alkenes are obtained with excellent stereoselectivity and broad functional group tolerance.  Water serves as the primary hydrogen source, while cost-efficient and readily available reagents and ligands are used.  Our reactions can be readily scaled-up in flow without compromising yield and stereoselectivity.

Networking Buffet Lunch in the Hotel Restaurant -- Network and Engage with Colleagues Over Lunch