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Integrated Lab-on-a-Chip Affinity and Electrophoresis Systems for Rapid Biomarker Quantitation
Adam Woolley, Associate Professor, Brigham Young University, United States of America

Integration in microfluidic systems enables new and improved analysis capabilities. The combination of affinity extraction with rapid electrophoretic analysis and other processes will be presented as a novel approach for rapid quantification of biomarkers in complex mixtures.

Analyte Concentration by Flow-Step Focusing
Peter Howell, Research Chemist, Naval Research Laboratory, United States of America

Carefully controlled removal of fluid at a T intersection is used to separate and concentrate analytes from a low background concentration. Concentration factors in the 100's are possible, and the concentrated band can be periodically and selectively released to downstream analysis.

Coffee Break and Networking in Exhibition Hall

Shrink-Film Fabrication for Lab on a Chip Applications
Michelle Khine, Associate Professor, University Of California Irvine, United States of America

Microfluidic Materials, Market and Trends
Frederic Breussin, Business Unit Manager, Yole Developpement, France

This paper provides data on the market of the main materials used for microfluidic applications and compares the different manufacturing processes.

Lunch and Networking in Exhibition Hall

Free Workshop
Single Sample, Single Slice, Single Prep, Single Well… Multiple Answers

Poster Viewing Session

Software Programmable Lab-on-a-Chip Applications and Optimization
Steve Wereley, Professor, Purdue University, United States of America

Our work concentrates on developing general purpose Lab-on-Chip devices that can perform a wide variety of assays simply by changing reagents and programming. We have also been bringing new multiphysics approaches to cell manipulation.

Coffee and Networking in Exhibition Hall

Integrated Microfluidic Devices – Case Studies from Automated Patch Clamp to Portable CD4 Cell Counting
Norbert Gottschlich, Key Account Manager, THINXXS MICROTECHNOLOGY AG, Germany

Examples of innovative approaches for realizing unit functions on chip will be shown. Examples of truly integrated microfluidic devices for point-of-care diagnostics and analytical applications will be presented.

Lab-on-a-Chip for Cell Sorting and PET Tracer Processing
Nicole Pamme, Professor in Analytical Chemistry, Stockholm University, Sweden

Lab-on-a-chip technology can act as a tool for medical applications. Two examples are presented here, namely (i) the sorting of magnetically labelled cells and (ii) the on-chip processing of radiopharmaceuticals employed in positron emission tomography (PET).

Visualizing the Genome using Micro-/ Nano-Fluidic Chips
Kalim Mir, Visiting Scholar, University of Oxford, United Kingdom

I will describe novel hybrid micro/nanofluidic devices for extraction and stretching of genomic DNA and obtaining sequence-based information in its native long-range linear context.

Opportunities and Pitfalls in Microfluidics Enabled Product Development
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH, Germany

As Lab-on-a-Chip technologies make their way into an ever increasing number of commercial products, it becomes noticeable that for complex integrated microfluidic devices certain protocols and development strategies have to be employed for a successful product development. We will present strategic and practical approaches with examples for such developments.

Drinks Reception

Next Generation Biosensing – Integrated Microfluidic for Point of Need Diagnostics
Frank Bier, Director, Fraunhofer Institute for Biomedical Engineering, Germany

To facilitate accurate measurements of molecular parameters for diagnostic puposes at the point of need various technologies have to be connected. This achieved bay the construction of autonomous biosensors.

Bionanoscience-based ICs for Innovative Global Healthcare Research & Technology (BIGHEART)
Luke Lee, Director, Global Health Research and Technology (BIGHEART), NUS, United States of America

I will discuss cellular BASICs (Biologic Application Specific Integrated Circuits) for quantitative biology and preventive personalized medicine: Self-powered Integrated Microfluidic Blood Analysis System (SIMBAS) and Optofluidic Application Specific Integrated System (OASIS).

Coffee and Networking in Exhibition Hall

Microdevices for Diagnosis of HIV and Sexually Transmitted Infections in Resource-Limited Settings
Curtis Chin, Lead Post Doctoral Fellow, Columbia University, United States of America

We present the development and evaluation of an integrated, low-cost, microfluidics-based assay for point-of-care diagnosis of HIV and sexually transmitted infections.

Human Tear Fluid-Based Point-of-Care Diagnostics Enabled by Integrated Microfluidic Systems
Kelly Karns, , University of California Berkeley, United States of America

We will detail a multiplexed microfluidic assay for validated autoimmune dysfunction biomarkers in human tear film fluids from healthy and Sjögren’s syndrome (SS) patients. This work is the first specific and rapid (< 3 min) microfluidic assay for biomarkers of dry eye disease in sparingly available ocular fluid.

Lunch and Networking in Exhibition Hall

Poster Viewing Session

Session: New Applications

Selective Culture and Analysis of Unattached Cancer Stem Cell Spheroids in a Microsystem
Ian White, Assistant Professor, University of Maryland, United States of America

Tumor cells with stem-like properties have been linked with relapse and metastasis. These so-called cancer stem cells uniquely form spherical colonies (called mammospheres for breast cancer) in low-attachment serum-free culture. We will present a microsystem that provides a low-attachment surface and a low-convection environment to enable mammospheres culture.

Coffee and Networking in Exhibition Hall

Microfluidic Tools for Studying Cells with Single Cell Resolution
Anup Singh, Post Doctoral Scientist, Sandia National Laboratories, United States of America

I will discuss development of innovative microfluidic platforms for studying the metagenome, genome and proteome of cells with single cell resolution.

Quantitative Analysis of Gene Expression at the Single-Cell Level with Microdroplet-Based Microfluidic Technology
Patrick Tabeling, Professor, ESPCI Paris Tech, France

The quantitative analysis of gene expression at the single-cell level is performed with microdroplet-based microfluidic technology. We measure the messenger RNA from total RNA and cells, in configurations suitable for achieving high throughput conditions.

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