08:00 | Registration |
09:30 |  | Keynote Presentation Regulatory Science – A Drug Development Perspective
Weida Tong, Director, US Food and Drug Administration, United States of America
Explain the FDA's new initiative on advancing regulatory science and its implication on drug development, describe three paradigms to enhance the drug pipeline and discuss three projects in FDA relating drug development via regulatory science. |
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Advances in Protein/Peptide Arrays and Biomarker Discovery |
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10:00 | Biomarker Discovery: SOMAscan and Clinical Data
Larry Gold, Chief Executive Officer/Chairman, SomaLogic, United States of America
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10:30 |  Technology Spotlight:
The Influence of Drop Drying on Chemical Reactivity: The Specific Case of Immobilization of Oligonucleotides on Microarray Surfaces
Jens Sobek, Research Scientist, University of Zurich
Drop drying is a key factor in a wide range of technical applications, including spotted microarrays. The applied nL liquid volume provides specific reaction conditions for the immobilization of molecules on a chemically modified surface. I report on the influence of nL and µL liquid drop volumes on the process of molecule immobilization and compare the results obtained with the situation in liquid solution. The data reveal a fundamental relationship between drop drying and surface chemistry on the one hand, and the selectivity of oligonucleotides, our model system, reacting with the surface on the other.
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10:45 | Coffee Break and Networking in Exhibition Hall |
11:15 | Dynamic Multi-Analyte Testing Technology for Accelerated Biomarker Measurement
Patrick van den Bogaard, Director, Biocartis, Switzerland
With the integration of semiconductor and microfluidics technologies we have developed a biomarker analysis platform that provides reproducible and high quality multiplex detection of proteins and nucleic acids in a very simple and short workflow. |
11:45 | An Integrated System Using Peptide Arrays to Assess Kinase and Nuclear Receptor Activities in Clinical Samples for Biomarker Development
Bertrand Jordan, Advisor, CoReBio PACA, France
A system developed around peptide microarrays allows real-time measurement of phosphorylations or interactions, with sophisticated software for data acquisition and interpretation. It is applied to kinase activity profiling and nuclear receptor-coregulator interactions, in order to develop biomarkers and diagnostic applications. |
12:30 | Lunch Break and Networking in Exhibition Hall |
13:30 | Poster Viewing Session |
14:15 | Protein and Peptide Arrays for Immune Studies
Paul Utz, Associate Professor, Stanford University School of Medicine, United States of America
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14:45 | Effect of Feature Selection and Sample Size on the Evaluation Genomic Classifiers
Sitan Yang, Research Assistant, Johns Hopkins University, United States of America
We investigate the predictive performance of a representative set of genomic classifiers under conditions of different feature selection methods and training sample sizes. We analyze these effects using MAQC-II breast cancer as well as simulated datasets. |
15:15 | Coffee Break and Networking in Exhibition Hall |
16:00 | Skinomics - The Use of Microarrays in Dermatology and Skin Biology
Miroslav Blumenberg, Associate Professor, NYU Langone Medical Center, United States of America
Due to accessibility skin and dermatology were among the earliest objects for microarray studies. Noninvasive skin sampling targeted melanomas; additionally, carcinomas, psoriasis, wound-healing, etc. have been analyzed. Recently, using microarrays identified genes specific for epidermal stem cells and those changing during keratinization. |
16:30 | Validation of Tissue Biomarkers
Stephen Hewitt, Clinical Investigator, National Institute of Health, United States of America
A data-driven review of the failure and means of improving tissue-based biomarker validation. |
17:00 | Drinks Reception and Networking in Exhibition Hall |
