Breakfast & Registration

Welcome Address from the Flow Chemistry Society
Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland

The Application of Flow Chemistry to the Manufacturing Route for MK8931
John Naber, Director, Flow Chemistry and Lab Automation, Process Research & Development, Merck & Co, United States of America

The development of a key step in the synthesis of Merck’s Phase III compound for Alzheimer’s disease from an initial lab scale hit through to a pilot plant campaign on hundreds of kilograms is presented.

Coffee & Networking in the Exhibition Hall

Accelerated C–H Activation Chemistry in Flow Microreactors
Timothy Noël, Professor, University of Amsterdam, Netherlands

Our group has focused on the development of more efficient C–H activation to establish carbon-carbon bonds, including the alkenylation and arylation of indoles and cross-dehydrogenative coupling reactions.

Shading Synthesis Green Using Enabling Technologies
Duncan Browne, Lecturer in Organic Chemistry, Cardiff University, United Kingdom

In this presentation I will discuss the development of continuous multistep process for the safe generation of diazonium salts followed by a green reduction by vitamin C to the corresponding hydrazines and subsequent cyclocondensation to afford a range of pyrazole products.

Advancing Continuous Processing Through Innovative External Collaborations
Scott May, Senior Research Advisor, Eli Lilly & Co, United States of America

This talk will highlight the results and benefits from several different LIFA and LRAP projects including continuous Asymmetric Hydroformylation, Aerobic Oxidation and Asymmetric Aza-Henry Reactions.

Lunch & Networking in the Exhibition Hall

Poster Viewing Session

Award Sponsored by 

Diazomethane without Tears. Or Explosions
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria

A simple and robust semi-batch apparatus for the generation of anhydrous solutions of diazomethane on laboratory scale is presented. Diazomethane is produced by base-mediated decomposition of Diazald within a semi-permeable Teflon AF-2400 tubing and subsequently selectively separated from the tubing into a flask.

Coffee & Networking in the Exhibition Hall

Preparative Fluoroalkylation via Visible Light Induced Electron Transfer
Corey Stephenson, Professor of Chemistry, Willard Henry Dow Laboratory, University of Michigan, United States of America

The development of visible light photocatalysis in flow will be presented focusing on radical fluoroalkylation reactions.

Automated Flow Peptide Synthesis: Toward Amide Bonds at Nature’s Pace
Brad Pentelute, Assistant Professor, Massachusetts Institute of Technology, United States of America

Here we describe a rapid flow solid phase peptide synthesis methodology that enables incorporation of an amino acid residue in forty seconds with amide-bond formation taking only five seconds. To demonstrate the broad applicability of this method, it was employed to synthesize hundreds of peptides and proteins.

Enz-Flow – The Union of Continuous Processing and Bioprocessing for Chemical Synthesis
Amanda Evans, Assistant Professor, California State University Fullerton, United States of America

In order to establish new, greener, precedents for generating active pharmaceutical ingredients (APIs), the Evans group is focused on advancing the fusion of continuous processing and bioprocessing technologies, or "Enz-Flow”.

Drinks Reception in the Exhibition Hall

Close of Day 1

Breakfast & Registration

Carbon Nanohoops in Continuous Flow
Ramesh Jasti, Associate Professor, Organic, Inorganic, Materials, and Supramolecular Chemistry, University of Oregon, United States of America

The cycloparaphenylenes, or carbon nanohoops, are the smallest possible slices of carbon nanotubes. In this presentation, I will describe my group's development of the key macrocyclization reaction in flow to prepare these materials.

Analyzing in Flow
Michael Organ, Professor, York University, Canada

Discussion will focus around the development of in-line sampling and analysis for reaction process optimization and production run monitoring.

Coffee & Networking in the Exhibition Hall

Towards Development of Chemo-Enzymatic Continuous-Flow Strategies for API’s Synthesis
Rodrigo de Souza, Associate Professor, Federal University of Rio De Janeiro, Brazil

Development of Chemo-enzymatic continuous-flow cascade reaction will be presented

Development of Continuous Flow Chemistry Using Online PAT
Matt Bio, President/CEO , Snapdragon Chemistry, United States of America

The integration and use of in-line process monitoring tools to facilitate the discovery and rapid optimization of flow chemistry processes will be discussed through case studies.

Novel Conditions for the Preparation of Diazo Reagents in Flow and their Applications
Andre Charette, Professor, Universite De Montreal, Canada

Diazo compounds are versatile reagents in organic synthesis. A new set of conditions has been developed for their preparation in continuous flow. The diazo reagents are produced in solution free of contaminants that may interfere with the subsequent reactions.

Lunch & Networking in the Exhibition Hall

Poster Viewing Session

Award Sponsored by

Developing A Compact, Portable 4.7 T Driven NMR System for At-Line Reaction Monitoring
David Strand, President & CEO, Protasis Corporation, United States of America

Historically, chemical reactor control has been challenging because composition measurements are often slow and non-specific. Compact, portable mid-field (200 – 400 MHz) NMR analyzers are now possible and will begin to provide practical composition measurements for research, pilot and production reactors in near-real-time. A first-of-kind, cryogen-free 200 MHz process NMR analyzer is described and initial reactor monitoring results are presented.

Development of Continuous Flow Micro-reactors for Fast Liquid and Liquid-liquid Reactions
Arturo Macchi, Professor of Chemical and Biological Engineering, University of Ottawa, Canada

The reactor design for fast liquid and liquid-liquid reactions was optimized based on the impact of phase physical properties, mixer geometry, method of energy input and scale.

Close of Conference, Coffee & Networking in the Exhibition Hall