08:00 | Conference Registration, Materials Pick-Up, Morning Coffee and Breakfast Pastries |
09:00 | Welcome Address by the Flow Chemistry Society Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland
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09:10 | Conference Chairs Welcome to Flow Chemistry Europe 2018 Mimi Hii, Professor, Imperial College London, United Kingdom Oscar de Frutos, Research Advisor / Group Leader, Eli Lilly and Company, Spain
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| Session 1 |
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09:15 | | Keynote Presentation Practical and Scalable Flow Synthesis Ian Baxendale, Professor, Durham University, United Kingdom
Aspects of Flow Chemistry from various case studies conducted within our laboratories in Durham. |
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10:00 | Recent Advances in Real Time Spectroscopy and Calorimetry for Monitoring Flow Chemistry Processes Stefan Lobbecke, Head of Department, Energetic Materials, Fraunhofer Institute for Chemical Technology, Germany
In this presentation we report on the development of spectroscopic and
calorimetric process analytical tools for the realtime monitoring of
chemical reactions in microfluidic processes.
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10:25 | Continuous Manufacturing at Novartis Pharma Joerg Sedelmeier, Principal Scientist Process R&D Chemist, Novartis, Switzerland
A “toolbox approach” to address ambitious project timelines will be
presented. A platform for conducting organolithium chemistry in
continuous flow mode, covering the scales from medicinal chemistry to
later phase process development will be described. |
10:50 | Coffee Break and Networking in the Exhibit Hall |
11:00 | Flexible API Supply Technologies; Continuous Technologies for Transformational Change in API Development and Manufacturing Nick Thomson, Senior Director, Chemical Research and Development , Pfizer, Inc., United States of America
I will provide an overview of the Pfizer strategy for API continuous
development and manufacturing and examples of newly developed continuous
technologies and product applications. |
11:25 | An Open-Source Approach to Low Cost Automation in Flow Chemistry Matthew O'Brien, Lecturer in Organic Chemistry, Keele University, United Kingdom
This presentation will discuss an open-sourced approach to low-cost Automation in Flow Chemistry.
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11:50 | New Chemical Applications in Continuous Flow Ryan Skilton, Research Scientist, Vapourtec Ltd
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12:20 | Immobilized Catalytic Systems for Asymmetric Flow Processses Miquel A. Pericàs, Professor, Institute of Chemical Research of Catalonia (ICIQ), Spain
In this lecture we will discuss different strategies for the
modification of homogeneous ligands and catalysts, in order to make
possible its covalent immobilization. Recent examples of the
development of some immobilized, yet highly active catalytic species for
enantioselective processes will be presented, and the development of
continuous flow processes based on these immobilized species will be
discussed. |
12:45 | Lunch and Networking in the Exhibit Hall |
14:30 | Additive Manufacturing Applied to Advanced Reactor Engineering Victor Sans Sangorrin, Assistant Professor, University of Nottingham, United Kingdom
In this presentation, the latest developments in the employment of
additive manufacturing, also known as 3D printing, to manufacture micro
and mesoscale continuous-flow reactors with advanced features, including
advanced mixing, heat exchange and supported biocatalysts will be
presented. |
14:55 | 3D Printed Reactors: From the Design of Inert Reactors through to Catalytic Devices for Continuous Flow Stephen Hilton, Associate Professor, University College London School of Pharmacy, United Kingdom
In this lecture we will describe the design and development of novel stereolithography (SLA) 3D printed catalyst impregnated reactors for continuous flow and their rapid evolution from simple inert fused deposition modeling (FDM) congeners. Their use in the easy transition from batch chemistry to flow will also be discussed. |
15:20 | The Use of Optimization Algorithms in Flow Francois-Xavier Felpin, Professor, University de Nantes, France
We will discuss reaction optimizations in flow, using of a modified
Simplex algorithm. The beneficial properties of flow reactors associated
to the power of optimization algorithms for the fine-tuning of
experimental parameters, allowed reactions to proceed in conditions
unable to promote the coupling through traditional batch chemistry. |
15:45 | Sub-Micromolar Reaction Screening in Flow Neal Sach, Associate Research Fellow, Pfizer, United States of America
A novel segmented flow technology is presented that enables sub-µmol
scale reaction screening. This step change in scale, compared with
typical batch methods, enables the potential to examine over 1500
combinations (solvent, base, catalyst, and temperature) automatically in
24 hours using just 15mg of substrate. The presentation will
demonstrate the technology through a model Suzuki coupling in which over
5000 combinations were completed in 4 days to arrive at a scalable
process suitable for scale up, or scale-out. |
16:10 | Coffee Break and Networking in the Exhibit Hall |
16:30 | Flow Synthesis of Pharmaceuticals: Feeding into an Emerging Pharmaceutical Manufacturing Industry in South Africa Darren Riley, Senior Lecturer, University of Pretoria, South Africa
This talk will highlight efforts to develop robust syntheses of critical
pharmaceuticals and will highlight efforts to use flow chemistry as an
enabling technology to improve existing “batch” based process routes. |
16:55 | Contribution of Material Inputs for Advanced Microreaction Technology Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH), Korea South
Advanced microreaction technologies have been achieved the best by chemistry and engineering together, rather than either alone. This talk shows typical cases of innovative reactor systems and process intensification by adopting multifunctional phenomena of new nanomaterials and nanostructures. |
| Session 2 |
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17:20 | | Keynote Presentation Multiphase Flow Chemistry for Demanding Catalytic Reactions Claude de Bellefon, CNRS & CPE Lyon, University of Lyon, France
In the last decade, innovating micro- and milli-structured multiphase
reactors have been developed allowing high mass and heat transfer
performances and opening new process windows. When a solid catalyst is
needed, it is often involved as a thin film deposited on the reactor or
channel walls, offering poor catalyst content per volume of reactor.
Also, catalyst handling and changeover in case of deactivation are
difficult and/or expensive. To face these issues, multiphase
micro-packed bed reactors operating with powdered catalysts have been
proposed albeit at the expense of very high pressure drop. The
alternative concept of open cell solid foam reactor is now well
established for gas-solid reactions and more and more works are
performed for multiphase gas-liquid or gas-liquid-solid reactors. In the
presentation comparisons to other reactors are proposed in terms of
hydrodynamics, heat, mass and momentum transfer performances for
demanding multiphase gas-liquid and gas-liquid-solid reactions. In
particular, demanding hydrogenations and oxidations are performed with
the idea is to look for possible synergetic effects by combining G-L
segmented flows and open cell solid foams to surpass the
characteristics obtained in the two separated systems (low pressure
drop, enhanced mixing, good thermal behaviour and mass transfer
capacities). |
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18:05 | Watching Homogeneous Catalysis with Real-time High Resolution Flow NMR Ulrich Hintermair, Whorrod Research Fellow/Professor, University of Bath, United Kingdom
I will present how operando reaction monitoring via continuous flow
on-line NMR spectroscopy enables rapid access to high-quality kinetic
data, and allows for mechanistic probe experiments leading to a better
understanding of the complex, dynamic processes occurring during
homogeneous catalysis in solution. |
18:30 | Poster Session with Pizza and Beer |
19:30 | Close of Day 1 of the Conference |