Andrew Hill,
Professor,
La Trobe University; ISEV President
Professor Andrew Hill gained his BSc(Hons) in Biochemistry and Molecular Biology from Victoria University of Wellington in New Zealand and his PhD at Imperial College, London. He held post-doctoral positions in the MRC Prion Unit (London) and in the Department of Pathology at the University of Melbourne as a Wellcome Trust Prize Travelling Research Fellow. Andrew joined the Department of Biochemistry and Molecular Biology at the University of Melbourne in 2002 and joined the Bio21 Institute when it opened in 2005. In 2015, he moved his laboratory to the La Trobe Institute of Molecular Sciences (LIMS) at La Trobe University where he is also Head of the Department of Biochemistry and Genetics. Andrews research team investigates the mechanisms involved in the spread of misfolded proteins associated with neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases. His laboratory studies the role that extracellular vesicles such as exosomes play a role in this process. Over the last five years his laboratory has developed an interest in extracellular vesicle RNA and investigated its potential as disease biomarkers for neurological and other conditions. He has been the recipient of several awards and prizes including a Victorian Young Tall Poppy Award in 2006, and the Edman Award (2005) and Merck Research Excellence Medal (2010) from the Australian Society for Biochemistry and Molecular Biology. He has held a number of competitive fellowships including an ARC Future Fellowship (FT3) and NHMRC Senior Research Fellowship. In 2016, Andrew was elected President of the International Society of Extracellular Vesicles (ISEV).
The Role of Extracellular Vesicles in Neurodegenerative Diseases
Tuesday, 26 September 2017 at 09:30
Add to Calendar ▼2017-09-26 09:30:002017-09-26 10:30:00Europe/LondonThe Role of Extracellular Vesicles in Neurodegenerative DiseasesExtracellular Vesicles 2017 in Cripps Court, Magdalene College, Cambridge, UKCripps Court, Magdalene College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com
Neurodegenerative disorders such as Alzheimer’s (AD), Parkinson’s (PD) and prion diseases are associated with proteins that misfold and deposit in the brain. Many cell types, including neurons, release extracellular vesicles (EVs) which include microvesicles and exosomes. EVs have been shown to be involved in processing of proteins such as APP, a-synuclein, and PrP which are those involved in AD, PD and prion diseases respectively. Roles for these vesicles include cell-cell signalling, removal of unwanted proteins, and transfer of pathogens (including prion-like misfolded proteins) between cells. In addition to their protein content these vesicles have recently been shown to contain genetic material in the form of protein coding (mRNA) and noncoding RNA species. We have analysed the protein and genetic cargo of EVs from a number of cell types and using deep sequencing, characterised the RNA cargo of these vesicles. Here, the role of extracellular vesicles in the pathogenesis and potential diagnosis of neurodegenerative diseases will be discussed.
Add to Calendar ▼2017-09-26 09:30:002017-09-26 10:30:00Europe/LondonThe Role of Extracellular Vesicles in Neurodegenerative DiseasesExtracellular Vesicles 2017 in Cripps Court, Magdalene College, Cambridge, UKCripps Court, Magdalene College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com
