Mass Spectrometric Approaches for Structural Elucidation of “Misfolding” - Aggregating Neurodegenerative Proteins: Ion Mobility- MS and Affinity- MSTuesday, 8 November 2011 at 16:30  Add to Calendar ▼2011-11-08 16:30:002011-11-08 17:30:00Europe/LondonMass Spectrometric Approaches for Structural Elucidation of “Misfolding” - Aggregating Neurodegenerative Proteins: Ion Mobility- MS and Affinity- MSMass Spectrometry Europe in Dublin, IrelandDublin, IrelandSELECTBIOenquiries@selectbiosciences.comRecent developments and applications of ion mobility mass spectrometry (IMS-MS) and affinity-mass spectrometry of the oligomerization- aggregation of ß-Amyloid and a-Synuclein, key proteins for Alzheimer’s and Parkinson’s Disease, enable the structure identification of hitherto unknown truncation, aggregation and modified products, providing molecular details of their mechanism of formation. IMS-MS of the in vitro oligomerization of a-Synuclein revealed highly aggregation-prone autoproteolytic fragments, such as the C-terminal fragment, aSyn(72-140). |
Add to Calendar ▼2011-11-08 00:00:002011-11-09 00:00:00Europe/LondonMass Spectrometry EuropeMass Spectrometry Europe in Dublin, IrelandDublin, IrelandSELECTBIOenquiries@selectbiosciences.com
