NRF2-mediated changes in Glutathione Metabolism mediate the resistance of EGFR-T790M Mutant Lung Cancer Cells to ErlotinibFriday, 26 May 2017 at 11:35 Add to Calendar ▼2017-05-26 11:35:002017-05-26 12:35:00Europe/LondonNRF2-mediated changes in Glutathione Metabolism mediate the resistance of EGFR-T790M Mutant Lung Cancer Cells to ErlotinibTargeted Cancer Therapies and Biofluid Biopsies in BengaluruBengaluruSELECTBIOenquiries@selectbiosciences.com The speaker will discuss about Metabonomics profiling of erlotinib-sensitive/resistant cells along with how, by using RNA interference and pharmacological inhibitors of GSH pathway enzymes, increasing GSH levels in ER cells sensitises these to erlotinib. Conversely, reducing GSH levels renders sensitive cells resistant to the drug. It will finally highlight how their data identifies a new resistance mechanism to EGFR TKIs and propose a novel therapeutic strategy to tackle this problem in the clinic. |