Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Extracellular Vesicle-based Dx & Rx Summit

Hollis Cline's Biography

Hollis Cline, Chair of Neuroscience and Hahn Professor of Neuroscience, The Scripps Research Institute

Hollis Cline, PhD, is the Hahn Professor of Neuroscience and co-chair of the Department of Neuroscience at Scripps Research in La Jolla, CA. She is a Councilor for the National Institute of Neurological Disorders and Stroke (NINDS), and has served on the council of the National Eye Institute (NEI) and on the Blue Ribbon Review Panel for the 10-year review of the National Institute of Child Health and Development (NICHD). Dr. Cline is a Fellow of the American Association for the Advancement of Science and has received the prestigious NIH Director’s Pioneer Award. Dr. Cline is a Past President of the Society for Neuroscience. She received her BA from Bryn Mawr College and her PhD from the University of California at Berkeley, followed by postdoctoral training at Yale University and Stanford University. She has served on the faculty of the University of Iowa and Cold Spring Harbor Laboratory, where she served as the Director of Research from 2002-2006. Dr. Cline’s research has demonstrated the roles of a variety of activity-dependent mechanisms in controlling structural plasticity of neuronal dendrites and axons, synaptic maturation and topographic map formation. This body of work has helped to generate a comprehensive understanding of the role of experience in shaping brain development. Two key points to emerge from her research is that circuit formation in vivo is a dynamic process throughout development that is continuously guided by experience, and that the basic mechanisms governing brain development, plasticity, information processing and organizational principles of brain circuits are highly conserved across vertebrates.

Hollis Cline Image

Exosome Signaling in Brain Development

Thursday, 28 March 2019 at 11:30

Add to Calendar ▼2019-03-28 11:30:002019-03-28 12:30:00Europe/LondonExosome Signaling in Brain DevelopmentExtracellular Vesicle-based Dx and Rx Summit in Coronado Island, CaliforniaCoronado Island,

Exosomes are thought to be secreted by all cells in the body and could to be involved in intercellular communication. I will describe experiments in which we tested whether neural exosomes regulate the development of neural circuits and whether exosome-mediated signaling may be aberrant in in vitro models of a neurodevelopmental disorder using human induced pluripotent stem cells (hiPSC) and in vivo rodent models. I will describe results of quantitative proteomic analysis of exosomes. Together our studies indicate that exosomes have the capacity to influence neuron and circuit development.

Add to Calendar ▼2019-03-28 00:00:002019-03-28 00:00:00Europe/LondonExtracellular Vesicle-based Dx and Rx SummitExtracellular Vesicle-based Dx and Rx Summit in Coronado Island, CaliforniaCoronado Island,