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SELECTBIO Conferences Innovations in Microfluidics 2020

M. Selim Ünlü's Biography

M. Selim Ünlü, Distinguished Professor of Engineering, Department of Electrical and Computer Engineering, Boston University

M. Selim Ünlü received the B.S. degree from the Middle East Technical University, Ankara, Turkey, in 1986, and the M.S.E.E. (1988) and Ph.D. (1992) degrees from the University of Illinois at Urbana-Champaign, all in electrical engineering. Since 1992, he has been a professor at Boston University. He is currently a Distinguished Professor of Engineering appointed in electrical and computer engineering, biomedical engineering, physics, materials science and engineering, and graduate medical sciences. He has also served as the Associate Dean for Research and Graduate Programs in engineering. His research interests are in the areas of nanophotonics and biophotonics focusing on high-resolution solid immersion lens microscopy of integrated circuits and development of biological detection and imaging techniques, particularly in high-throughput digital biosensors based on detection of individual biological nanoparticles, viruses, and single molecule counting.

Dr. Ünlü has presented hundreds of invited talks at conferences, departmental colloquia and other research institutions and participated in international conference organizations. He has authored and co-authored ~200 journal articles and has over 10,000 citations (h-index of 52); edited one book; and holds 15 US/international patents. Dr. Ünlü was the recipient of the NSF CAREER and ONR Young Investigator Awards in 1996. He has been selected as a Photonics Society Distinguished Lecturer for 2005-2007 and Australian Research Council Nanotechnology Network (ARCNN) Distinguished Lecturer for 2007. He has been elevated to IEEE Fellow rank in 2007 for his “contributions to optoelectronic devices” and OSA Fellow rank in 2017 for his “for pioneering contributions in utilization of optical interference in enhanced photodetectors and biological sensing and imaging.” In 2008, he was awarded the Science Award by the Turkish Scientific Foundation. His professional service includes serving as the Editor-in-Chief for IEEE Journal of Quantum Electronics.

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Interferometric Detection: From Multiplexed Label-free Affinity Measurements to Counting Single Biomolecules

Monday, 6 July 2020 at 12:30

Add to Calendar ▼2020-07-06 12:30:002020-07-06 13:30:00Europe/LondonInterferometric Detection: From Multiplexed Label-free Affinity Measurements to Counting Single Biomolecules Innovations in Microfluidics 2020 in Boston, USABoston,

Interferometric reflectance imaging sensor (IRIS) technology is based on interference of light from an optically transparent thin film—the same phenomenon that gives rainbow colors to a soap film when illuminated by white light. IRIS has two modalities: (i) low-magnification (ensemble biomolecular mass measurements) allowing for multiplexed affinity measurements and (ii) high-magnification (digital detection of individual nanoparticles) along with their applications, including label-free detection of multiplexed protein chips, measurement of single nucleotide polymorphism, quantification of transcription factor DNA binding, and high sensitivity digital sensing and characterization of nanoparticles and viruses.

In vitro tests are a cornerstone of clinical practice, with the sensitivity of standard immunoassays measuring protein biomarkers at picomolar concentrations. This level of sensitivity is sufficient for the diagnosis of infectious diseases when clear symptoms are present, however it falls short significantly for the detection of molecular biomarkers that are important in cancer, neurological disorders, and the early stages of infection as well as environmental sensing.  Perhaps one of the most exciting recent technological developments in biomarker analysis is single-molecule counting or digital detection, an approach that provides resolution and sensitivity beyond the reach of ensemble measurements. In this presentation, we will cover the technical developments of IRIS platform as well as our efforts in technology commercialization.

Add to Calendar ▼2020-07-06 00:00:002020-07-07 00:00:00Europe/LondonInnovations in Microfluidics 2020Innovations in Microfluidics 2020 in Boston, USABoston,