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SELECTBIO Conferences Exosomes & Liquid Biopsies Europe 2018

Florent Mouliere's Biography



Florent Mouliere, Researcher, Nitzan Rosenfeld Group, University of Cambridge

Florent is a postdoctoral researcher at the Cancer Research UK Cambridge Institute, University of Cambridge. He received his Msc. in bioengineering from the Ecole des Mines d’Ales and a Ph.D. in molecular biology from the University of Montpellier, France. He joined Nitzan Rosenfeld's Laboratory at the University of Cambridge at the end of 2013. His interests are tailoring new sequencing technologies and multi-omics analysis to study the biology of circulating nucleic acids. These methods will improve the sensitivity of liquid biopsy in difficult pathological contexts (early detection, MRD and brain tumours) and expand the utility of ctDNA to new clinical applications.

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Improving the Detection of Circulating Tumour DNA in Plasma by Selecting Short DNA Fragments

Friday, 26 October 2018 at 08:00

Add to Calendar ▼2018-10-26 08:00:002018-10-26 09:00:00Europe/LondonImproving the Detection of Circulating Tumour DNA in Plasma by Selecting Short DNA FragmentsExosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

The sensitivity for detecting the presence of genomic changes in circulating tumour DNA (ctDNA) is limited by its low concentration in plasma. Here I will present new approaches tailoring sequencing to the biological properties of ctDNA for improving the detection of rare mutant molecules. In particular, we studied the feasibility for enrichment of ctDNA by physical and in-silico size selection in plasma samples collected from multiple cancer types. Size selection of short DNA fragments enriches for ctDNA, unlocking un-targeted genome-wide sequencing for liquid biopsy.


Add to Calendar ▼2018-10-24 00:00:002018-10-26 00:00:00Europe/LondonExosomes and Liquid Biopsies Europe 2018Exosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com