Anirban Ghosh's Biography

Anirban Ghosh, Research Scientist, Atlantic Cancer Research Institute (ACRI)

Dr. Ghosh's current research mainly focuses on development of clinically-adaptable capturing technologies of exosome or extracellular vesicles (EVs) for diagnostic as well fundamental research. EVs are membrane-encapsulated nano-vesicles (30 to 300 nm) that transport cargoes of active molecules to proximal, distal cells via body fluids. Secreted EVs also contain real-time information on the physiological and pathological status of their cells of origin and can be used for minimally invasive early detection and diagnosis of disease from various body fluids ushering in the concept of a "surgery-less biopsy". Though very promising, the development of EVs-capture technologies has been hampered by the current enrichment/isolation methods of EVs where techniques like ultracentrifugation are viewed as bottle-necks for the advancement of clinical applications and antibody based capture methods lack specificity. Dr. Ghosh's research discovered and validated EVs capture technologies which will have wide application in EV based therapy and/or diagnostics not only for cancer and other human diseases but also for applications in animal care/ food industries. Dr. Ghosh's research also focus on developing Lab-On-Chip based Bio-Micro-Electro-Mechanical Systems (BioMEMS) to adapt ACRI’s proprietary EVs-capture technologies suitable for next-generation diagnostic platforms. These platforms have wide scope and potential for point-of-care early detection of many diseases and infections integrated to one Chip of human and animal health and for other potential use in food quality controls. Dr. Ghosh's research also focuses on the biology of hyaluronic acid in cancer initiation and progression.