| Conferences \ RNA-Seq, Single Cell Analysis & Single Molecule Analysis 2017 \ Agenda \ Zhibo Yang |
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Towards Quantitative Mass Spectrometry Analysis of Live Single Cells Using the Single-Probe DeviceThursday, 5 October 2017 at 11:30  Add to Calendar ▼2017-10-05 11:30:002017-10-05 12:30:00Europe/LondonTowards Quantitative Mass Spectrometry Analysis of Live Single Cells Using the Single-Probe DeviceRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.comRecent developments in bioanalytical MS areas greatly depend on the advancements in sampling and ionization methods. We have developed a miniaturized multifunctional device, the Single-probe, for microscale bioanalysis. One of the important applications is to conduct quantitative analysis of compounds (such as anticancer drugs) inside live single cells. The Single-probe is fabricated by embedding within the dual-bore quartz needle with one fused silica capillary and one nano-ESI emitter. The tip size of the Single-probe is small enough (6-9 µm) to be inserted into a live eukaryotic cell for sampling. The sampled cellular compounds are immediately ionized along with an internal standard (such as deuterated drug), and detected by a mass spectrometer. The abundance of target molecules can be obtained from experimental results. |
Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonRNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017RNA-Seq, Single Cell Analysis and Single Molecule Analysis 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
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