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SELECTBIO Conferences Circulating DNA, Circulating RNA, Circulating Tumor Cells

Saumya Das's Biography

Saumya Das, Assistant Professor in Medicine, Beth Israel Deaconess Medical Center and Mass General Hospital

Saumya Das M.D., Ph.D. is an Assistant Professor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School and part of the Cardiovascular Institute. He is the lead PI of an NIH Common Fund Grant for studying extracellular RNAs as biomarkers in cardiovascular diseases, and his laboratory focuses on discovery of novel extracellular RNA biomarkers, understanding their role as mediators of intercellular communication, and developing therapeutic strategies using animal models.

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A Functional Role for Extracellular RNAs as Biomarkers in Cardiovascular Diseases

Monday, 23 March 2015 at 17:30

Add to Calendar ▼2015-03-23 00:00:002015-03-23 01:00:00Europe/LondonA Functional Role for Extracellular RNAs Biomarkers in Cardiovascular

As the treatment for acute coronary syndromes has improved in the last decade, the sequelae of myocardial infarction such as heart failure and ventricular arrhythmias have increasingly contributed to morbidity, mortality and health care expenditure. Novel strategies to understand ventricular remodeling after myocardial infarction and onset of heart failure are critical to development of novel biomarkers to identify vulnerable patients and novel pathways for therapeutic intervention. Biomarkers that are functionally implicated in disease pathogenesis may be particularly robust and shed light on novel disease specific pathways. This presentation focuses on novel extracellular RNA biomarkers present in different plasma compartments and discusses their role as diagnostic and prognostic biomarkers. The specific case of microRNA-30d as a prognostic biomarker for cardiac remodeling and its functional role in remodeling is discussed in detail. The application and challenges of next generation sequencing to discover novel extracellular RNA biomarkers are addressed.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor