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SELECTBIO Conferences Microfluidics for Circulating Biomarkers Summit 2019

Maiwenn Kersaudy-Kerhoas's Biography



Maiwenn Kersaudy-Kerhoas, Associate Professor, School of Engineering and Physical Sciences, Heriot-Watt University

Dr Kersaudy-Kerhoas’ research has focused on the development of microfluidic tools for the preparation of human blood samples prior to analytical detection of biomarkers such as DNA, RNA and microRNA. This involves the design of hydrodynamic plasma separation features and the integration of nucleic acid extraction into microfluidic workflows. She works closely with biologists and clinicians to develop applications in the field of non-invasive prenatal testing, cancer and beyond.

Her interests in Manufacturing Research lie in micro and nanotechnologies, rapid prototyping and the development of cost-effective manufacturing processes for medium to high volume production of polymeric microfluidic components. She is also interested in the replacement of petroleum-derived products by composites derived from renewable resources in the production of high-value microsystems.

In 2017, she won the £1.3M UK Engineering and Physical Sciences Research Council Healthcare Technology Challenge Award (2018-2022).

Maiwenn Kersaudy-Kerhoas Image

Near-Patient, Automated Platform for Rapid Microfluidic Extraction of Circulating Nucleic Acids from Milliliter Volumes of Whole Blood

Thursday, 10 October 2019 at 14:00

Add to Calendar ▼2019-10-10 14:00:002019-10-10 15:00:00Europe/LondonNear-Patient, Automated Platform for Rapid Microfluidic Extraction of Circulating Nucleic Acids from Milliliter Volumes of Whole BloodMicrofluidics for Circulating Biomarkers Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Extracellular plasma circulating cell-free nucleic acids (CNAs) are promising clinical biomarkers but their measurement remains time-consuming, technically challenging and expensive. For CNAs to have an impact on healthcare, a key challenge to overcome is the development of rapid and reliable low-cost sample preparation. There is an acknowledged issue around CNAs stability in the presence of hemolysis, and few solutions for fast and robust extraction at the site of blood draw. We demonstrate a microfluidic system able to perform the extraction of circulating miRNAs from several milliliters of whole blood in a single disposable fluidic cartridge, on a fully automated platform, delivering a stable elution of CNAs in less than 45 minutes. The biological characterization of the eluates include qPCR, fluorometric and spectrophotometric analysis, and automated electrophoresis for fragment analysis. This platform enables the standardization of sample preparation at the point of blood draw and in resource limited settings and could aid the introduction of CNAs-based assays into routine clinical practice.


Add to Calendar ▼2019-10-10 00:00:002019-10-10 00:00:00Europe/LondonMicrofluidics for Circulating Biomarkers Summit 2019Microfluidics for Circulating Biomarkers Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com