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SELECTBIO Conferences Circulating DNA, Circulating RNA, Circulating Tumor Cells

Shannon Stott's Biography

Shannon Stott, Assistant Professor, Massachusetts General Hospital & Harvard Medical School

Shannon Stott, Ph.D., is an Assistant Professor in the Department of Medicine at Harvard Medical School and an Assistant in Genetics at the Massachusetts General Hospital Center for Cancer Research. Her laboratory is comprised of bioengineers, physicists and chemists focused on translating technological advances to relevant applications in clinical medicine. Specifically, Shannon is interested in using microfluidics and imaging technologies to create tools that increase understanding of cancer biology and of the metastatic process. In collaboration with the Toner, Haber and Maheswaran laboratories, Shannon has developed microfluidic devices that can isolate extraordinary rare circulating tumor cells (CTCs) from the blood of cancer patients. Her research also includes novel microfluidic devices for extracellular vesicle isolation and molecular characterization with a goal of earlier cancer detection.

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Microfluidic Isolation and Molecular Characterization of Glioblastoma Extracellular Vesicles

Tuesday, 24 March 2015 at 14:30

Add to Calendar ▼2015-03-24 14:30:002015-03-24 15:30:00Europe/LondonMicrofluidic Isolation and Molecular Characterization of Glioblastoma Extracellular

Extracellular vesicles (EVs) released from cancer cells into the bloodstream contain genetic information about the primary tumor. These EVs have the potential to be used for early diagnosis as well as to guide treatment, but can be challenging to reliably assay due to the heterogeneous population of MVs released from normal cells.  We have taken a microfluidic approach to isolate these tumor derived MVs from serum from glioblastoma patients. In this talk, I will describe our latest technology for EV capture as well as the results of our molecular analysis of these EVs. Our data demonstrates that tumor-derived MVs can be selectively captured from serum, providing a less invasive method to obtain genetic information about the patient’s tumor.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor