Dolores Di Vizio,
Professor,
Cedars Sinai Medical Center
Dr. Dolores Di Vizio is a pathologist and a molecular and cell biologist trained at Albert Einstein College of Medicine, and Harvard Medical School. Dr. Di Vizio holds an academic appointment as associate professor at Cedars-Sinai Medical Center, and at the University of California, Los Angeles. She is an Executive Chair of the International Society of Extracellular Vesicles (ISEV). Her group studies the molecular mechanisms of progression to advanced disease in human tumors, with a particular emphasis on large oncosomes, extracellular vesicles (EVs) shed into the extracellular space from fast migrating and metastatic amoeboid cancer cells. Her lab is currently profiling the large oncosomes and other EV populations by NGS and proteomics for functional and molecular characterization.
Biological Functions and Methods of Detection of Large Oncosomes in Cancer
Thursday, 28 March 2019 at 08:30
Add to Calendar ▼2019-03-28 08:30:002019-03-28 09:30:00Europe/LondonBiological Functions and Methods of Detection of Large Oncosomes in CancerLiquid Biopsies 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Extracellular Vesicles (EVs) are important mediators of intercellular
communication pathways that lead to tumor progression, and potential
sources for discovery of novel cancer biomarkers. Recent studies have
shed light on the existence of different populations of cancer-derived
EVs. These heterogeneous EV populations exhibit distinct molecular
cargo, thus pointing to the possibility that the various EV populations
might play diverse roles in cancer and that this does not happen
randomly. However, data attributing cancer specific intercellular
functions to given populations of EVs are still limited. A deeper
functional, biochemical and molecular characterization of the various EV
classes might identify more selective clinical markers, and
significantly advance our knowledge of the pathogenesis and disease
progression of many cancer types. We demonstrated that atypically large
EVs can be shed from highly migratory and metastatic cancer cells. These
EVs, named large oncosomes, play distinct functions and contain a
specific repertoire of molecules that can be used for detection of
tumor-derived cargo in plasma.
Add to Calendar ▼2019-03-27 00:00:002019-03-29 00:00:00Europe/LondonLiquid Biopsies 2019Liquid Biopsies 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-03-28 08:30:002019-03-28 09:30:00Europe/LondonBiological Functions and Methods of Detection of Large Oncosomes in CancerLiquid Biopsies 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
