Frederik Claeyssens's Biography

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Emulsion Templated Scaffolds with Tuneable Mechanical Properties for Bone-on-a -Chip Devices

Thursday, 9 July 2015 at 08:30

Add to Calendar ▼2015-07-09 08:30:002015-07-09 09:30:00Europe/LondonEmulsion Templated Scaffolds with Tuneable Mechanical Properties for Bone-on-a -Chip DevicesSELECTBIOenquiries@selectbiosciences.com

An important self-assembly route for porous polymeric materials manufacture is emulsion templating via high internal phase emulsions (HIPEs) where typically a dispersed aqueous droplet phase is used with a curable pre-polymer continuous phase. During the curing process a foam is produced where the pores are interconnected (a polyHIPE). Here I will highlight our recent research efforts on using these polyHIPEs in combination with UV-based curing and stereolithography to make hierarchical structures where the internal porosity is governed by self-assembly and the macroscopic structure is constructed by additive manufacturing. These 3D structured scaffolds are produced with varying mechanical properties via changing the monomer mixing ratio to make the polyHIPE structures. These materials have an interconnected internal microporosity of ~10-50 µm, while the macroscale features are defined by the additive manufacturing process. Culturing of human embryonic stem cell-derived mesenchymal progenitors (hES-MPs) reveals that the scaffolds support osteogenic differentiation. Additionally, cells proliferate and penetrate into the micro- and macro-porous architecture. The presented hybrid manufacturing technique addresses the resolution trade-off between macro structuring with micro resolution, while maintaining user control over porosity throughout the process. This work illustrates the excellent potential of these hierarchical structured scaffolds for constructing bone-on-a-chip devices.