David Kolesky,
Research Scientist,
Harvard University and The Wyss Institute for Bioloigcally Inspired Engineering
As a Ph.D. student in Jennifer Lewis’ lab at Harvard University, David developed a method 3D bioprinting of vascularized, heterogeneous tissues. Through a combination of materials, engineering, and biological advances, this work laid the ground work for follow on papers including the creation of thick vascularized tissue ~1 cm in thickness, and tissue specific proximal tubule model suitable for disease modeling and drug screening. His work has been featured in top peer reviewed publications and popular press outlets. Notably, in 2015 David was awarded first prize in National Collegiate Inventor’s Competition for graduate students, an annual prize given by the US patent office for the year’s top graduate student inventor.
3D Bioprinting and Perfusion of Vascularized Tissues
Thursday, 16 March 2017 at 16:00
Add to Calendar ▼2017-03-16 16:00:002017-03-16 17:00:00Europe/London3D Bioprinting and Perfusion of Vascularized TissuesSELECTBIOenquiries@selectbiosciences.com
Engineered thick living tissue constructs could enable new in vitro applications in 3D cell studies, drug screening, disease modeling, and, ultimately, therapeutic applications in regenerative medicine. We will highlight our recent efforts on concurrent patterning of cells and vasculature, along with new strategies to achieve active perfusion, long-term stability of thick living tissues (> 1cm thick), all of which are essential for creating a physiologically and therapeutically relevant tissue manufacturing method. As a demonstration of complex architecture and function at a physiologically relevant size scales, we directly differentiate patterned hBM-MSCs towards the osteogenic lineage via the in situ delivery of various factors through a pervasive vascular network, illustrating control over the long-term growth and development of our printed tissue. With control over multicellular architecture, the chemo-mechanical microenvironment, and the ability to support thick, developing tissue for long time points, this method could serve as a platform for studying emergent biological functions in complex engineered micro-environments, and, may ultimately, find applications in vivo.
Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/London3D-Bioprinting, Tissue Engineering and Synthetic BiologySELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-03-16 16:00:002017-03-16 17:00:00Europe/London3D Bioprinting and Perfusion of Vascularized TissuesSELECTBIOenquiries@selectbiosciences.com
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