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SELECTBIO Conferences PharmaAQ

Trupti Tol's Biography



Trupti Tol, Associate Director, Cipla Ltd

Ms Trupti, an Associate Director, leads a dynamic analytical QbD team at Cipla Pharmaceuticals. She has a rich 15 years’ experience in various analytical techniques such as liquid chromatography, Gas chromatography and Particle size analysis. Ms Trupti was instrumental in implementing QbD across the analytical domain at Cipla. She has published her innovative works in different journals including “Journal of Chromatography A”. Ms Trupti has presented her work as a speaker in many National and International conferences held in India and abroad. She has a master’s degree in Organic Chemistry for the University of Mumbai and is also certified Six Sigma Black Belt.

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Optimization of a Liquid Chromatography Method for the Analysis of Related Substances using Design of Experiments Integrated with the Steepest Ascent Method and Monte Carlo Simulation

Friday, 12 October 2018 at 12:30

Add to Calendar ▼2018-10-12 12:30:002018-10-12 13:30:00Europe/LondonOptimization of a Liquid Chromatography Method for the Analysis of Related Substances using Design of Experiments Integrated with the Steepest Ascent Method and Monte Carlo SimulationPharmaAQ in MumbaiMumbaiSELECTBIOenquiries@selectbiosciences.com

An analytical method for the determination of related substances (RS) was optimised using quality by design (QbD) approach. The DoE study uncovered hidden peaks and unknown criticalities, which would eventually lead to method and product failure.  Since this was a sensitive case of method development it was treated accordingly, and techniques such as method of steepest ascent were adopted to attain the optimum condition. Finally, the method robustness was proved and fortified through capability analysis and Monte Carlo simulations and this is going to be a focus of Ms Tol’s talk.


Add to Calendar ▼2018-10-11 00:00:002018-10-12 00:00:00Europe/LondonPharmaAQPharmaAQ in MumbaiMumbaiSELECTBIOenquiries@selectbiosciences.com