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SELECTBIO Conferences Emerging Themes and Technologies in Tissue Engineering and Bioprinting

Anthony Melchiorri's Biography

Anthony Melchiorri, , Fischell Department of Bioengineering

My work investigates the development of biomaterial strategies for the vascular applications. Previous published studies have examined the use of polymeric biofelt grafts, chemical surface modification of vascular grafts, and biodegradable vascular graft characterization. Recent efforts have examined 3D printing techniques and biomaterials designed for regenerative medicine and cardiovascular applications.

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Three Dimensional Printing of Biodegradable Cardiovascular Biomaterials

Tuesday, 10 February 2015 at 15:30

Add to Calendar ▼2015-02-10 15:30:002015-02-10 16:30:00Europe/LondonThree Dimensional Printing of Biodegradable Cardiovascular

Rapid advances in three dimensional (3D) printing, whether based on extrusion or lithography, are bringing the technology closer to clinical use in tissue engineering.  3D printing allows for precise bulk geometry and interior architecture control.  Based upon material selection, the resolution of the interior and bulk geometry can typically range from 25 µm to 100 µm.  Using 3D printing, we have developed biodegradable scaffolds with custom pore sizes.  These scaffolds have been non-destructively analyzed with microcomputed tomography to calculate changes in scaffold pore size, porosity, and wall thickness during a 16 week degradation study.  One potential clinical application of 3D printing is for the treatment of cardiovascular diseases, through which outcomes may be drastically improved with custom fabrication of patient-specific grafts.  Current clinical strategies rely upon surgeons constructing tailor-made implants during surgery with generic grafts.  Advancements in imaging technologies, such as MRI and CT, allow for the production of high-quality 3D images from which patient-specific grafts and implants can be generated prior to surgery.  To this end, we have formulated a poly(propylene fumarate) (PPF) based resin to 3D print vascular features with mechanical properties similar to native blood vessels.  The grafts support the growth of vascular cells in vitro and support good neotissue formation after one and three months in vivo.  Further, these grafts may be modified with biomolecules, such as VEGF, so as to recruit and mobilize endothelial cell populations and thus quicken graft endothelialization.

Add to Calendar ▼2015-02-09 00:00:002015-02-10 00:00:00Europe/LondonEmerging Themes and Technologies in Tissue Engineering and