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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2024

Andrew J deMello's Biography

Andrew J deMello, Professor of Biochemical Engineering & Institute Chair, ETH Zürich

Andrew is currently Professor of Biochemical Engineering in the Department of Chemistry & Applied Biosciences at ETH Zürich, and until October 2020 was Head of the Institute for Chemical and Bioengineering. Prior to his arrival in Zurich, he was Professor of Chemical Nanosciences and Head of the Nanostructured Materials and Devices Section in the Chemistry Department at Imperial College London. His research interests cover a broad range of activities in the broad areas of microfluidics and nanoscale science. Primary specializations include the development of microfluidic devices for high-throughput biological and chemical analysis, ultra-sensitive optical spectroscopies, microfluidic tools for material synthesis and clinical diagnostic technologies.

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Real-Time Viscoelastic Deformability Cytometry

Monday, 24 June 2024 at 09:00

Add to Calendar ▼2024-06-24 09:00:002024-06-24 10:00:00Europe/LondonReal-Time Viscoelastic Deformability CytometryLab-on-a-Chip and Microfluidics Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

Differences in the mechanical properties of diseased cells and their benign counterparts means that mechanical phenotyping of cells can be used to report both cellular state and function. Accordingly, the ability to perform such measurements in a robust and high-throughput manner suggests potential utility in the detection and diagnosis of disease. Whilst different methods for cellular mechanophenotyping have been described, the ability to perform high-throughput single-cell deformability measurements on liquid or solid tissue biopsies remains an unmet challenge within clinical settings. To address this issue, we have developed viscoelastic deformability cytometry (vDC), a microfluidic method able to measure the mechanical properties of single cells at rates of up to 100,000 cells per second. Fluid viscoelasticity is used to both focus and deform cells without the need for sheath fluids. We have used vDC for cell phenotyping of both liquid and solid tumor biopsies, cytoskeletal drug analysis, and identifying malignant lymphocytes in peripheral blood samples. vDC offers new opportunities for high-throughput, label-free single cell analysis, with diverse applications in clinical diagnostics and personalized medicine.

Add to Calendar ▼2024-06-24 00:00:002024-06-25 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2024Lab-on-a-Chip and Microfluidics Europe 2024 in Rotterdam, The NetherlandsRotterdam, The