Noah Malmstadt,
Professor, Mork Family Dept. of Chemical Engineering & Materials Science,
University of Southern California
Noah Malmstadt is Professor at the University of Southern California. He received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. Malmstadt is the recipient of a 2012 Office of Naval Research Young Investigator award. His research focuses on microfluidic strategies to facilitate material fabrication and biophysical analysis. He has pioneered the integration of ionic liquids as solvents in droplet microreactors and the application of microfluidic systems to synthesizing biomimetic cell membranes. Microfluidic analytical techniques he has developed include methods for measuring the permeability of cell membranes to druglike molecules and techniques for measuring ionic currents through membrane proteins.
Understanding Three-Dimensional Microfluidic Design to Optimize Lipid Nanoparticle Fabrication
Thursday, 7 November 2024 at 12:00
Add to Calendar ▼2024-11-08 15:00:002024-11-08 16:00:00Europe/LondonTitle to be Confirmed: Flow Chem-focused PresentationLab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
3D printing brings with it a plethora of advantages for microfluidic applications. Principle among these are rapid prototyping, iterative design, and the ability to avoid the cost and overhead of cleanrooms. However, there is also an inherent advantage in being able to design and build devices in a truly three-dimensional, rather than layer-by-layer, geometry. One simple domain in which the advantages of true 3D routing are clear is in mixing. Control over a 3D geometry allows for multiple complex mixing configurations--herringbones, relamination mixers, chaotic advection--to be trivially constructed and recombined. We have deployed these principles of 3D design to design simple, compact devices for the high-throughput manufacture of lipid nanoparticles (LNPs). LNPs are drug delivery vehicles of increasing importance: they have demonstrate effectiveness and scalability as the delivery vehicles for mRNA-based vaccines against SARS-CoV-2 and emerging research is demonstrating that they have broad applications in vaccine delivery and beyond. This talk discusses how microfluidic mixing controls the size, structure, and uniformity of LNPs with several drug-like payloads including mRNA and therapeutic peptides.
Add to Calendar ▼2024-11-07 00:00:002024-11-08 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024Lab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2024-11-08 15:00:002024-11-08 16:00:00Europe/LondonTitle to be Confirmed: Flow Chem-focused PresentationLab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
