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SELECTBIO Conferences Exosomes-EV-based Therapeutics Summit

Danilo Tagle's Biography

Danilo Tagle, Associate Director For Special Initiatives, Office of the Director, National Center for Advancing Translational Sciences at the NIH (NCATS)

Dan Tagle is associate director for special initiatives at NCATS. He also recently served as acting deputy director of NCATS and has served as acting director of the NCATS Office of Grants Management and Scientific Review and as executive secretary to the NCATS Advisory Council and Cures Acceleration Network Review Board. Prior to joining NCATS, Tagle was a program director for neurogenetics at the National Institute of Neurological Disorders and Stroke (NINDS), where he was involved in developing programs concerning genomics-based approaches for basic and translational research in inherited brain disorders.

Prior to joining NINDS in 2001, Tagle was an investigator and section head of molecular neurogenetics at the National Human Genome Research Institute and has been involved in the highly collaborative effort toward the positional cloning of genes for Huntington’s disease, ataxia-telangiectasia and Niemann-Pick disease type C. He has served on numerous committees and advisory boards, including the editorial boards of the journals Gene and the International Journal of Biotechnology.

Tagle obtained his Ph.D. in molecular biology and genetics from Wayne State University School of Medicine in 1990. He was an NIH National Research Service Award postdoctoral fellow in human genetics in the laboratory of Francis S. Collins, M.D., Ph.D., at the University of Michigan. Tagle has authored more than 150 scientific publications and has garnered numerous awards and patents.

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The NIH Extracellular RNA Communication Consortium: Advancing Knowledge and Technologies for Extracellular RNA Research

Friday, 1 November 2019 at 12:00

Add to Calendar ▼2019-11-01 12:00:002019-11-01 13:00:00Europe/LondonThe NIH Extracellular RNA Communication Consortium: Advancing Knowledge and Technologies for Extracellular RNA ResearchExosomes-EV-based Therapeutics Summit in Rotterdam, The NetherlandsRotterdam, The

The discovery that secreted RNA (exRNA) is transported between cells through extracellular vesicles (EVs) suggested that exRNAs plays an important role in intercellular communication. Moreover, exRNAs also have utility as biomarkers of disease and as therapeutic agents. However, many gaps in knowledge and technical challenges in EVs and exRNA biology, such as mechanisms of EV biogenesis and uptake, exRNA cargo selection, and exRNA function. Moreover, efficient and reproducible methods for isolation and analysis of EVs and exRNAs were not available. The NIH Common Fund-supported exRNA Communication Consortium (ERCC) was launched in 2013 to address the major scientific challenges in this field. Participating laboratories from the 30 funded ERCC projects have worked individually and collaboratively to work toward these goals. This presentation will highlight the ERCC tools and resources developed, and scientific highlights particularly in biomarker discovery and therapeutic development of EV-based exRNA.

Add to Calendar ▼2019-11-01 00:00:002019-11-01 00:00:00Europe/LondonExosomes-EV-based Therapeutics SummitExosomes-EV-based Therapeutics Summit in Rotterdam, The NetherlandsRotterdam, The