Jing Yang's Biography

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3D Bioprinting of Personalized Nasal Scaffolds

Thursday, 9 July 2015 at 14:00

Add to Calendar ▼2015-07-09 14:00:002015-07-09 15:00:00Europe/London3D Bioprinting of Personalized Nasal ScaffoldsSELECTBIOenquiries@selectbiosciences.com

In the case of a particularly aggressive or mature nasal cancer, the surgical solution is to remove the whole nose from skin down to skeleton. A total nasal reconstruction is then undertaken if the defect site is confirmed to be cancer free. Current gold standard for reconstruction after rhinectomy or severe trauma includes transposition of autologous cartilage grafts in conjunction with autologous mucosal flaps and coverage using a skin flap. The difficulty of this approach is the limited amount of autologous cartilage and mucosa from donor sites to achieve a satisfactory aesthetic and functional reconstruction. Moreover, harvest of autologous cartilage requires a major additional procedure which creates donor site morbidity. We have developed a method for making scaffolds for nasal reconstruction using 3D printing. In particular, we have developed a printing method that allows us to control the shell porosity of the printed scaffolds. Cell penetration into the scaffolds has been found to be improved with higher shell porosity. The co-printing of a cell-laden hydrogel and a polymer into a scaffold has also been demonstrated.