Kennedy Okeyo,
Senior Lecturer, Institute for Frontier Life and Medical Sciences,
Kyoto University
Dr. Kennedy O. Okeyo is currently a senior lecturer at the Institute for Frontier Life and Medical Sciences, Kyoto University. He graduated with a PhD in mechanical engineering from Kyoto University, Japan, and worked briefly in a company thereafter. Prior to his current appointment, he worked as an assistant professor at the Department of Mechanical Engineering, The University of Tokyo, Japan. His current research interests includes tissue engineering, biomicrofluidics, and cellular biomechanics, with specific focus on stem cell function manipulation based on cell-material interactions.
Organoids as Emergent Systems Inducible by Designing the Adhesion Microenvironment of Stem Cells
Monday, 14 October 2019 at 16:30
Add to Calendar ▼2019-10-14 16:30:002019-10-14 17:30:00Europe/LondonOrganoids as Emergent Systems Inducible by Designing the Adhesion Microenvironment of Stem CellsStem Cells in Drug Discovery Tox and Organoids 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
The adhesion microenvironment plays important contributory roles in the
induction of self-organized tissue formation and differentiation of
pluripotent stem cells (PSCs). However, how the interaction with the
surrounding physical microenvironment influences the complex processes
of self-organization and differentiation which orchestrate organoid
formation by stem cells remains to be fully understood. In this
research, we are examining how the local adhesion microenvironment, as
characterized by both cell-substrate and cell-cell adhesions, can
trigger self-organization and differentiation globally, and lead to the
emergence of higher-order structures such as organoids from lower-order
cellular systems. To this end, we have developed a simple but versatile
culture platform, namely, the micromesh culture technique which employs
adhesion-limiting microstructured mesh substrates to modulate adhesion
microenvironment and trigger self-organization of stem cells into
ordered 3D structures in a manner which mimics tissue morphogenesis.
This talk will highlight our recent findings that modulating the cell
adhesion microenvironment by our culture technique can potentially
trigger stem cells to exhibit differentiation and self-organization as
seen in early embryogenesis, such as the emergence of the trophectoderm
and primordial germ cells (PGCs), even under pluripotency maintaining
culture conditions in vitro.
Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonStem Cells in Drug Discovery Tox and Organoids 2019Stem Cells in Drug Discovery Tox and Organoids 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-10-14 16:30:002019-10-14 17:30:00Europe/LondonOrganoids as Emergent Systems Inducible by Designing the Adhesion Microenvironment of Stem CellsStem Cells in Drug Discovery Tox and Organoids 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
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