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SELECTBIO Conferences The RNA Summit: Research, Diagnostics & Therapeutics

Ashish Lal's Biography

Ashish Lal, Investigator and Head, Regulatory RNAs and Cancer Section, Genetics Branch, National Cancer Institute (NCI)

My laboratory studies the roles of Regulatory RNAs in colorectal cancer. We have examined the biology of microRNAs downstream of wild-type p53 during DNA damage and in the regulation of cell migration, invasion and metastasis by hot-spot gain-of-function mutant p53 proteins. More recently, much of my lab has shifted to studying long non-coding RNAs (lncRNAs). As compared to the well-studied microRNAs, the function and mechanism of action of the vast majority of lncRNAs remains a mystery. We have identified novel p53-regulated lncRNAs in colorectal cancer cells and are investigating if and how they mediate the effects of p53 during DNA damage. Current efforts in my lab are focused on 2 p53-regulated lncRNAs that we named PURPL and PINCR. Our results suggest that PURPL and PINCR are pro-survival p53-regulated lncRNAs that mediate their effects in trans, via distinct mechanisms.

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Regulating the Regulator: lncRNAs in the p53 Network

Monday, 13 November 2017 at 14:30

Add to Calendar ▼2017-11-13 14:30:002017-11-13 15:30:00Europe/LondonRegulating the Regulator: lncRNAs in the p53 NetworkThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston,

Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of the vast majority remains to be investigated. We have identified and functionally characterized two nuclear-retained lncRNAs that we termed PINCR (p53 induced noncoding RNA) and PURPL (p53-upregulated regulator of p53 levels). Our results show that both PINCR and PURPL function as pro-survival lncRNAs in vitro and in vivo. Mechanistically, PINCR and PURPL mediate the effect of p53 in colorectal cancer cells by regulating p53 itself or by modulating the expression of a subset of p53 targets via distinct mechanisms. These studies reveal critical roles of PINCR and PURPL in the p53 network and uncover unique modes by which lncRNAs function.

Add to Calendar ▼2017-11-13 00:00:002017-11-14 00:00:00Europe/LondonThe RNA Summit: Research, Diagnostics and TherapeuticsThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston,