José Manuel García-Aznar,
Professor, Mechanical Engineering, Mechanical and Biological Engineering Research group (M2BE),
University of Zaragoza
José Manuel García-Aznar received his PhD in Mechanical Engineering in 1999 from University of Zaragoza, where he serves since 2008 as Full Professor in the Mechanical Engineering Department. In these years, he has been visiting researcher at Keele University (2001), KU Leuven (2012), Cambridge University (2015) and NUI Galway (2017). In 2004, he was elected as Council Member of the European Society of Biomechanics (ESB) (2004-2012), and finally as Vice-President (2008-2012). More recently, in 2012 he was awarded by the ERC with a Starting Grant project that allows him extending his computational expertise to 3D cell cultures in microfluidic devices to understand basic mechanisms of cell migration. He is author of over 120 JCR papers with more than 3300 citations. His research interests focus on the computational modelling of mechanics of hard tissues, mechanobiology of skeletal tissue regeneration and tissue engineering, tissue growth and development and cell mechanics. Most recently his research work has also focused on the combination of computational models and microfluidics-based experiments in order to investigate the mechanisms that regulate cell migration and tissue formation.
The Role of Scaffold Architecture in Guiding Tissue Growth: From Modeling to Microfluidics
Wednesday, 18 October 2017 at 11:45
Add to Calendar ▼2017-10-18 11:45:002017-10-18 12:45:00Europe/LondonThe Role of Scaffold Architecture in Guiding Tissue Growth: From Modeling to MicrofluidicsBioprinting and 3D Printing in the Life Sciences Europe in Cripps Court, Magdalene College, Cambridge, UK Cripps Court, Magdalene College, Cambridge, UK SELECTBIOenquiries@selectbiosciences.com
Safe and effective regeneration of tissues require a high control of cellular response, which is dependent on multiple microenvironment cues, such as: extracellular matrix composition and architecture, cell-cell and cell-matrix interaction, interstitial fluid flow, growth factors, etc. In this work, we will investigate how scaffolds can regulate cell migration by means of the appropriate architecture. Actually, we present a combination of computational and in-vitro techniques to determine how scaffold architecture guide cell movement and consequently tissue growth. Multiscale computational modeling of tissue regeneration has predictive capabilities for the rational design of functional scaffolds that induce tissue growth and biomaterial degradation, regulating an adequate regeneration. Realistic, mechanistic models can provide a framework for understanding the fundamental mechano-chemical interactions between cells, material and fluid flow. Microfluidics is a powerful tool that allows in-vitro testing of 3D hydrogel-based scaffolds, due to their characteristics of recreating healing conditions, providing the possibility of co-culture different cell types. In fact, hydrogels are confined in chambers, which are connected with channels to control these microenvironmental conditions. In this work, we will present different computational approaches to analyze various regulatory mechanisms for guiding tissue growth, individual and collective cell migration. These advanced simulations will be complemented with the corresponding in-vitro experiments that will allow validating some of the conclusions provided by the numerical models. Therefore, different kinds of multiscale and multiphysics models are integrated in order to understand fundamental cellular processes that will help us to define the most adequate scaffold architecture for the successful guidance of tissue regeneration.
Add to Calendar ▼2017-10-17 00:00:002017-10-18 00:00:00Europe/LondonBioprinting and 3D Printing in the Life Sciences EuropeBioprinting and 3D Printing in the Life Sciences Europe in Cripps Court, Magdalene College, Cambridge, UK Cripps Court, Magdalene College, Cambridge, UK SELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-10-18 11:45:002017-10-18 12:45:00Europe/LondonThe Role of Scaffold Architecture in Guiding Tissue Growth: From Modeling to MicrofluidicsBioprinting and 3D Printing in the Life Sciences Europe in Cripps Court, Magdalene College, Cambridge, UK Cripps Court, Magdalene College, Cambridge, UK SELECTBIOenquiries@selectbiosciences.com
