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SELECTBIO Conferences Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches
Conferences  \  Organ-on-a-Chip World Congress & 3D-Culture 2017  \  Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches  \  Agenda  \  Pulak Nath
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Pulak Nath's Biography


Pulak Nath, Technical Staff Member, Applied Modern Physics, Los Alamos National Laboratory

Dr. Pulak Nath established the Magnetics, Microfluidics, and Miniaturization lab at the Applied Modern Physics Group (P-21), Los Alamos National Laboratory (LANL), Los Alamos, NM. Dr. Nath received his Doctor of Engineering (D.Eng.) degree in Biomedical Engineering from a joint program offered by the Cleveland Clinic/Cleveland State University. He completed his MS and BS in Chemical Engineering from the University of Dayton and the Bangladesh University of Engineering and Technology, respectively. His laboratory is involved in developing novel permanent magnets for use in portable NMR and magnetic particle manipulation applications; automated sample preparation for medical diagnostics; droplet microfluidic platforms to study cell-cell interactions; genetically engineered ‘magnetic’ algae for biofuels and bio/nano-product; and a rapid prototyping method to develop complex bioreactors such as organs-on-a-chip. Dr. Nath currently leads the engineering effort for a DTRA (Defense Threat Reduction Agency) funded project focusing on the development of multiple organs on a chip. Their work on the miniaturized tissue-engineered lung (PuLMo) has received an R&D 100 award and FLC (Federal Lab Consortium) Mid-Continent Regional Award in 2016.

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PuLMo: Configurable tools for Human Lung Micro-Physiological Systems

Tuesday, 11 July 2017 at 13:30

Add to Calendar ▼2017-07-11 13:30:002017-07-11 14:30:00Europe/LondonPuLMo: Configurable tools for Human Lung Micro-Physiological SystemsSELECTBIOenquiries@selectbiosciences.com

PuLMo (Pulmonary Lung Models) represents a suite of enabling platforms to obtain user defined and integrated lung micro-physiological models, which has received an R&D100 award in 2016. A stepwise approach was taken to develop a suite of micro-engineered units to enable configurable and integrated MPS models for drug toxicity analysis. PuLMo was designed to recapitulate multiple critical features of the human lung. PuLMo incorporates the biophysical features of (1) air-liquid interface; (2) fractal airway network; (3) balloon shaped alveolar chambers; (4) cyclic stretching of the alveolar membrane; and (5) physiological breathing. PuLMo’s biological features included (1) ciliated cells; (2) mucus production; and (3) surfactant production. The platforms were fabricated using hybrid (subtractive + additive) manufacturing, allowing the integration of a wide range of materials. The stretchable alveolar membranes were fabricated using polyurethane. Breathing was carried out by stretching the alveoli membrane with a novel microfluidic aspiration principle. While the complexity of the integrated platform can be defined by the user, complete operation of PuLMo can require the perfusion and transition of multiple media. Therefore miniaturized pumps, valves, fluid circuit boards, and reservoirs were also developed to enable integrated operations. This presentation will give an overview of all the novel technologies that led to the R&D 100 award.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and 3D-Culture: Companies, Technologies and ApproachesSELECTBIOenquiries@selectbiosciences.com


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